Integrin beta 3 Antikörper

Produktnummer ABIN2689351

Zitiert in 3+ Publikationen. Der Maus Monoklonal anti-Integrin beta 3 Antikörper (Klon F11) (ABIN2689351) detektiert spezifisch Integrin beta 3 in FACS, IP, IHC (fro), BR, IHC (f) und IHC (zinc). Dieser Antikörper reagiert spezifisch mit Proben aus Ratte.

Kurzübersicht für Integrin beta 3 Antikörper (ABIN2689351)

Target: Integrin beta 3 (ITGB3)

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Integrin beta 3 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Blocking Reagent (BR), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Zinc-fixed Sections) (IHC (zinc))

Klon: F11

Produktdetails anti-Integrin beta 3 Antikörper

Produktmerkmale: The F11 antibody reacts with the integrin β3 chain (CD61), which associates with the integrin αv chain (CD51), to form the vitronectin receptor found on endothelial cells, myeloid cells, and osteoclasts, and with the αIIb chain (CD41) on platelets and megakaryocytes. Both receptors mediate adhesion to fibronectin, fibrinogen, vitronectin, thrombospondin, and von Willebrand factor. F11 mAb has been reported to block the in vitro attachment of osteoclasts to several ligands. Weak reactivity with human osteoclasts, megakaryocytes, and platelets has also been observed. Other reported applications include immunoprecipitation, in vitro blocking, and immunohistochemical staining (IHC) of acetone-fixed frozen and zinc-fixed paraffin-embedded sections. IHC of formalin-fixed paraffin-embedded sections is not recommended.

BD Pharmingen™ Purified Mouse Anti-Rat CD61 - Purified - Clone F11 - Isotype Mouse IgG1, κ - Reactivity Rat - 0.5 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Rat bone cell suspensions

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-Integrin beta 3 Antikörper (ABIN2689351)

Helfrich, Nesbitt, Dorey, Horton: "Rat osteoclasts adhere to a wide range of RGD (Arg-Gly-Asp) peptide-containing proteins, including the bone sialoproteins and fibronectin, via a beta 3 integrin." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 7, Issue 3, pp. 335-43, (1992) (PubMed).

Helfrich, Nesbitt, Horton: "Integrins on rat osteoclasts: characterization of two monoclonal antibodies (F4 and F11) to rat beta 3." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 7, Issue 3, pp. 345-51, (1992) (PubMed).

Kieffer, Phillips: "Platelet membrane glycoproteins: functions in cellular interactions." in: Annual review of cell biology, Vol. 6, pp. 329-57, (1991) (PubMed).

Details zu Integrin beta 3

Target: Integrin beta 3 (ITGB3)

Andere Bezeichnung: CD61

Hintergrund: Synonyms: Integrin β3 chain

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex