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ITGA5 Antikörper

Dieses Ratte Monoklonal-Antikörper erkennt spezifisch ITGA5 in FACS, IHC (fro), IF, IHC (p) und BR. Er zeigt eine Reaktivität gegenüber Maus und wurde in 10+ Publikationen erwähnt.
Produktnummer ABIN2689316

Kurzübersicht für ITGA5 Antikörper (ABIN2689316)

Target

Alle ITGA5 Antikörper anzeigen
ITGA5 (Integrin, alpha 5 (ITGA5))

Reaktivität

  • 112
  • 77
  • 25
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Maus

Wirt

  • 91
  • 26
  • 15
  • 5
  • 1
Ratte

Klonalität

  • 81
  • 58
Monoklonal

Konjugat

  • 75
  • 11
  • 11
  • 9
  • 5
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser ITGA5 Antikörper ist unkonjugiert

Applikation

  • 82
  • 51
  • 45
  • 43
  • 23
  • 16
  • 15
  • 14
  • 13
  • 13
  • 10
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Blocking Reagent (BR)

Klon

5H10
  • Marke

    BD Pharmingen™

    Produktmerkmale

    The 5H10-27 (MFR5) antibody reacts with the α5 chain of the integrin α5β1 fibronectin receptor (CD49e/CD29, VLA-5) on thymocytes, activated T lymphocytes, mast cells, and a variety of mouse cell lines, but not splenocytes. Soluble 5H10-27 (MFR5) antibody has been reported to inhibit VLA-5-mediated functions in vitro. In addition, immobilized mAb 5H10-27 (MFR5) has been demonstrated to costimulate the proliferative response of CD8+ T cells to plate-bound anti-CD3e antibody. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature.

    BD Pharmingen™ Purified Rat Anti-Mouse CD49e - Purified - Clone 5H10-27 (MFR5) - Isotype Rat IgG2a, κ - Reactivity Ms - 0.5 mg

    Aufreinigung

    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

    Immunogen

    Mouse mast cell line MC/9

    Isotyp

    IgG2a kappa
  • Applikationshinweise

    Optimal working dilution should be determined by the investigator.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    0.5 mg/mL

    Buffer

    Aqueous buffered solution containing ≤0.09 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store undiluted at 4°C.
  • Makwana, Werner, Acosta-Saltos, Gonitel, Pararajasingam, Pararajasingham, Ruff, Rumajogee, Cuthill, Galiano, Bohatschek, Wallace, Anderson, Mayer, Behrens, Raivich: "Peripheral facial nerve axotomy in mice causes sprouting of motor axons into perineuronal central white matter: time course and molecular characterization." in: The Journal of comparative neurology, Vol. 518, Issue 5, pp. 699-721, (2010) (PubMed).

    Cukierman, Pankov, Stevens, Yamada: "Taking cell-matrix adhesions to the third dimension." in: Science (New York, N.Y.), Vol. 294, Issue 5547, pp. 1708-12, (2001) (PubMed).

    Yang, Hynes: "Fibronectin receptor functions in embryonic cells deficient in alpha 5 beta 1 integrin can be replaced by alpha V integrins." in: Molecular biology of the cell, Vol. 7, Issue 11, pp. 1737-48, (1997) (PubMed).

    Rich, Van Nood, Lee: "Role of alpha 5 beta 1 integrin in TGF-beta 1-costimulated CD8+ T cell growth and apoptosis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 157, Issue 7, pp. 2916-23, (1996) (PubMed).

    Ruppert, Aigner, Hubbe, Yagita, Altevogt: "The L1 adhesion molecule is a cellular ligand for VLA-5." in: The Journal of cell biology, Vol. 131, Issue 6 Pt 2, pp. 1881-91, (1996) (PubMed).

    Uhlenkott, Huijzer, Cardeiro, Elstad, Meadows: "Attachment, invasion, chemotaxis, and proteinase expression of B16-BL6 melanoma cells exhibiting a low metastatic phenotype after exposure to dietary restriction of tyrosine and phenylalanine." in: Clinical & experimental metastasis, Vol. 14, Issue 2, pp. 125-37, (1996) (PubMed).

    Gomez, Cano: "Expression of beta 1 integrin receptors in transformed mouse epidermal keratinocytes: upregulation of alpha 5 beta 1 in spindle carcinoma cells." in: Molecular carcinogenesis, Vol. 12, Issue 3, pp. 153-65, (1995) (PubMed).

    Halvorson, Coligan: "Enhancement of VLA integrin receptor function on thymocytes by cAMP is dependent on the maturation stage of the thymocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 155, Issue 10, pp. 4567-74, (1995) (PubMed).

    Hardy, Minguell: "Modulation of the adhesion of hemopoietic progenitor cells to the RGD site of fibronectin by interleukin 3." in: Journal of cellular physiology, Vol. 164, Issue 2, pp. 315-23, (1995) (PubMed).

    Kinashi, Springer: "Adhesion molecules in hematopoietic cells." in: Blood cells, Vol. 20, Issue 1, pp. 25-44, (1995) (PubMed).

  • Target

    ITGA5 (Integrin, alpha 5 (ITGA5))

    Andere Bezeichnung

    CD49e

    Hintergrund

    Synonyms: Integrin α5 chain

    Pathways

    Integrin Complex
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