CD4 Antikörper

Produktnummer ABIN2689220

Dieser Maus Monoklonal Antikörper detektiert spezifisch CD4 in FACS. Es zeigt Reaktivität gegenüber Proben von Rhesusaffen, Cynomolgus und Pavian. Es wurde in 4+ Publikationen zitiert.

Kurzübersicht für CD4 Antikörper (ABIN2689220)

Target: CD4

Reaktivität: Rhesusaffen, Cynomolgus, Pavian

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: L200

Produktdetails anti-CD4 Antikörper

Produktmerkmale: The L200 antibody reacts with the human form of the 56 kDa transmembrane glycoprotein, CD4, present on the T-helper/inducer subset of normal human donor peripheral blood lymphocytes. L200 antibody also cross-reacts with a subset of CD3-positive peripheral blood lymphocytes, but not monocytes, of both rhesus and cynomolgus macaque monkeys. Cross-reactivity on both lymphocytes and monocytes (weak) of baboon is also observed. The distribution on lymphocytes is similar for both human and monkey, with the majority of CD4-positive lymphocytes being CD8-negative and lacking reactivity with antibodies to B- or NK-cell markers. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of anti-CD4 reactivity on peripheral blood lymphocytes of rhesus macaque (Macaca mulatta) analyzed by flow cytometry

BD Pharmingen™ Purified Mouse Anti-Human CD4 - Purified - Clone L200 - Isotype Mouse IgG1, κ - Reactivity Bab, Cyno, Rhe - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-CD4 Antikörper (ABIN2689220)

Verdier, Aujoulat, Condevaux, Descotes: "Determination of lymphocyte subsets and cytokine levels in cynomolgus monkeys." in: Toxicology, Vol. 105, Issue 1, pp. 81-90, (1996) (PubMed).

Jacobsen, Aasted, Broe, Petersen: "Reactivities of 20 anti-human monoclonal antibodies with leucocytes from ten different animal species." in: Veterinary immunology and immunopathology, Vol. 39, Issue 4, pp. 461-6, (1994) (PubMed).

Indzhiia, Yakovleva, Overbaugh, Licciardi, Chikobava, Klotz, Torres, Indzhiia, Lapin, Clark: "Baboon T cell lymphomas expressing the B cell-associated surface proteins CD40 and Bgp95." in: Journal of clinical immunology, Vol. 12, Issue 3, pp. 225-36, (1992) (PubMed).

Powell, McClure, Anderson, Fultz, Sell, Ahmed-Ansari: "Phenotypic and functional differences in NK and LAK cells in the peripheral blood of sooty mangabeys and rhesus macaques." in: Cellular immunology, Vol. 124, Issue 1, pp. 107-18, (1989) (PubMed).

Details zu CD4

Target: CD4

Andere Bezeichnung: CD4

Pathways: T-Zell Rezeptor Signalweg, Maintenance of Protein Location, CXCR4-mediated Signaling Events