NCR1 Antikörper

Produktnummer ABIN2689196

Dieses Maus Monoklonal-Antikörper erkennt spezifisch NCR1 in FACS. Er zeigt eine Reaktivität gegenüber Human und wurde in 4+ Publikationen erwähnt.

Kurzübersicht für NCR1 Antikörper (ABIN2689196)

Target: NCR1 (Natural Cytotoxicity Triggering Receptor 1 (NCR1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NCR1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: 9E2-NKp46

Produktdetails anti-NCR1 Antikörper

Marke: BD Pharmingen™

Produktmerkmale: The 9E2/Nkp46 monoclonal antibody specifically binds to CD335. CD335 is also known as the Natural killer cell p46-related protein (NKp46) and the Natural cytotoxicity triggering receptor 1 (NCR1). CD335 is a 46 kDa type I membrane glycoprotein that is expressed on resting and activated NK cells. Its extracellular region contains two C2-type, Ig-like domains. The transmembrane domain contains a positively charged amino acid (Arg) which could be involved in stabilizing the association with CD3ζ. Its intracellular region does not contain immunoreceptor tyrosine-based activating motifs (ITAM), but it is linked to intracytoplasmic transduction machinery by its association with CD3ζ and FcεRIγ adaptor proteins. CD335 along with NKp30 and NKp44 are referred to as natural cytotoxicity receptors (NCR). These receptors play very important roles in cells that kill virus-infected target cells, tumor cells and MHC-class I-unprotected cells. Profile of CD335 (NKp46) reactivity on peripheral blood lymphocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.

BD Pharmingen™ Purified Mouse Anti-Human CD335 (NKp46) - Purified - Clone 9E2/NKp46 (also known as 9-E2) - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-NCR1 Antikörper (ABIN2689196)

Mandelboim, Porgador: "NKp46." in: The international journal of biochemistry & cell biology, Vol. 33, Issue 12, pp. 1147-50, (2001) (PubMed).

Nakajima, Cella, Bouchon, Grierson, Lewis, Duckett, Cohen, Colonna: "Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity." in: European journal of immunology, Vol. 30, Issue 11, pp. 3309-18, (2001) (PubMed).

Sivori, Pende, Bottino, Marcenaro, Pessino, Biassoni, Moretta, Moretta et al.: "NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human NK cells. Correlation between surface density of NKp46 and natural cytotoxicity against ..." in: European journal of immunology, Vol. 29, Issue 5, pp. 1656-66, (1999) (PubMed).

Sivori, Vitale, Morelli, Sanseverino, Augugliaro, Bottino, Moretta, Moretta: "p46, a novel natural killer cell-specific surface molecule that mediates cell activation." in: The Journal of experimental medicine, Vol. 186, Issue 7, pp. 1129-36, (1997) (PubMed).

Details zu NCR1

Target: NCR1 (Natural Cytotoxicity Triggering Receptor 1 (NCR1))

Andere Bezeichnung: CD335 NKp46

Pathways: Regulation of Leukocyte Mediated Immunity