CCR6 Antikörper (Biotin)

Produktnummer ABIN2689058

Produktdetails anti-CCR6 Antikörper (Biotin)

Target: CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CCR6 Antikörper ist konjugiert mit Biotin

Applikation: Flow Cytometry (FACS)

Marke: BD Pharmingen™

Produktmerkmale: The monoclonal antibody 11A9 reacts with the human CC chemokine receptor, CCR6. CCR6 (previously known as BN-1, CKR-L3, DRY6, GPR-CY4 and STRL22), a seven-transmembrane, G-protein-coupled receptor, is the specific receptor for CC chemokine MIP-3a/LARC/ Exodus. It has been shown that CCR6 mRNA is expressed mainly in lymphoid tissues including spleen, lymph nodes, thymus, appendix. CCR6 mRNA was also detected in peripheral T- and B-lymphocytes and in CD34-derived dendritic cells. The human CCR6 gene, unlike other CCR genes, has been mapped to chromosome 6q27. The immunogen used to generate 11A9 hybridoma was KLH-conjugated N-terminus peptides of human CCR6. It does not cross-react with human CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CCR8, CCR9, CXCR1, CXCR2, CXCR3, CXCR4 and CXCR5 transfectants. This antibody is NOT a neutralizing antibody. CCR6 had been clustered as CD196 in the VIIIth HLDA workshop. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Expression of human CCR6 on peripheral lymphocytes detected by biotinylated 11A9.

BD Pharmingen™ Biotin Mouse Anti-Human CD196 (CCR6) - Biotin - Clone 11A9 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.5 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Klon: 11A9

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Referenzen für anti-CCR6 Antikörper (Biotin) (ABIN2689058)

Baba, Imai, Nishimura, Kakizaki, Takagi, Hieshima, Nomiyama, Yoshie: "Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC." in: The Journal of biological chemistry, Vol. 272, Issue 23, pp. 14893-8, (1997) (PubMed).

Greaves, Wang, Dairaghi, Dieu, Saint-Vis, Franz-Bacon, Rossi, Caux, McClanahan, Gordon, Zlotnik, Schall: "CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cells." in: The Journal of experimental medicine, Vol. 186, Issue 6, pp. 837-44, (1997) (PubMed).

Liao, Alderson, Su, Ullrich, Kreider, Farber: "STRL22 is a receptor for the CC chemokine MIP-3alpha." in: Biochemical and biophysical research communications, Vol. 236, Issue 1, pp. 212-7, (1997) (PubMed).

Liao, Lee, Farber: "Cloning of STRL22, a new human gene encoding a G-protein-coupled receptor related to chemokine receptors and located on chromosome 6q27." in: Genomics, Vol. 40, Issue 1, pp. 175-80, (1997) (PubMed).

Power, Church, Meyer, Alouani, Proudfoot, Clark-Lewis, Sozzani, Mantovani, Wells: "Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3alpha from lung dendritic cells." in: The Journal of experimental medicine, Vol. 186, Issue 6, pp. 825-35, (1997) (PubMed).

Zaballos, Varona, Gutiérrez, Lind, Márquez: "Molecular cloning and RNA expression of two new human chemokine receptor-like genes." in: Biochemical and biophysical research communications, Vol. 227, Issue 3, pp. 846-53, (1996) (PubMed).

Details zu CCR6

Target: CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))

Andere Bezeichnung: CD196 CCR6 (CCR6 Produkte)

Synonyme: BN-1 antikoerper, C-C CKR-6 antikoerper, CC-CKR-6 antikoerper, CCR-6 antikoerper, CD196 antikoerper, CKR-L3 antikoerper, CKRL3 antikoerper, CMKBR6 antikoerper, DCR2 antikoerper, DRY6 antikoerper, GPR29 antikoerper, GPRCY4 antikoerper, STRL22 antikoerper, Cmkbr6 antikoerper, KY411 antikoerper, C-C motif chemokine receptor 6 antikoerper, chemokine (C-C motif) receptor 6 antikoerper, CCR6 antikoerper, Ccr6 antikoerper

Hintergrund: Synonyms: CCR6

Pathways: cAMP Metabolic Process