CD19 Antikörper

Produktnummer ABIN2689047

Es sind 4+ Publikationen für dieses Produkt verfügbar. Der Maus Monoklonal anti-CD19 Antikörper wird verwendet zum Nachweis von CD19 in Proben von Human. Er wurde validiert für FACS, IHC (fro) und FM.

Kurzübersicht für CD19 Antikörper (ABIN2689047)

Target: CD19 (CD19 Molecule (CD19))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD19 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Fluorescence Microscopy (FM)

Klon: HIB19

Produktdetails anti-CD19 Antikörper

Produktmerkmale: Reacts with the 95 kDa type I transmembrane glycoprotein expressed during all stages of B-cell differentiation and maturation, except on plasma cells. CD19 is also present on follicular dendritic cells. It is not found on T cells or on normal granulocytes. CD19 plays a role in regulation of B-cell proliferation. It associates with the complement receptor 2 (CD21), TAPA-1 (CD81), Leu 13, and/or MHC class II to form a signal transduction complex on the surface of B cells. Anti-CD19 clone HIB19 partially blocks clone B43, another C19 mAb. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of peripheral blood lymphocytes analyzed on a FACScan

BD Pharmingen™ Purified Mouse Anti-Human CD19 - Purified - Clone HIB19 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-CD19 Antikörper (ABIN2689047)

Bradbury, Goldmacher, Tedder: "The CD19 signal transduction complex of B lymphocytes. Deletion of the CD19 cytoplasmic domain alters signal transduction but not complex formation with TAPA-1 and Leu 13." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 151, Issue 6, pp. 2915-27, (1993) (PubMed).

Favaloro, Moraitis, Koutts, Exner, Bradstock: "Endothelial cells and normal circulating haemopoietic cells share a number of surface antigens." in: Thrombosis and haemostasis, Vol. 61, Issue 2, pp. 217-24, (1989) (PubMed).

Uckun, Muraguchi, Ledbetter, Kishimoto, OBrien, Roloff, Gajl-Peczalska, Provisor, Koller: "Biphenotypic leukemic lymphocyte precursors in CD2+CD19+ acute lymphoblastic leukemia and their putative normal counterparts in human fetal hematopoietic tissues." in: Blood, Vol. 73, Issue 4, pp. 1000-15, (1989) (PubMed).

Nadler, Anderson, Marti, Bates, Park, Daley, Schlossman: "B4, a human B lymphocyte-associated antigen expressed on normal, mitogen-activated, and malignant B lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 131, Issue 1, pp. 244-50, (1983) (PubMed).

Details zu CD19

Target: CD19 (CD19 Molecule (CD19))

Andere Bezeichnung: CD19

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung