FCGR3A Antikörper (Biotin)

Produktnummer ABIN2689011

Es sind 7+ Publikationen für dieses Produkt verfügbar. Der Maus Monoklonal anti-FCGR3A Antikörper wird verwendet zum Nachweis von FCGR3A in Proben von Ratte. Er wurde validiert für FACS.

Kurzübersicht für FCGR3A Antikörper (Biotin) (ABIN2689011)

Target: FCGR3A (Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A))

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FCGR3A Antikörper ist konjugiert mit Biotin

Applikation: Flow Cytometry (FACS)

Klon: 10-78

Produktdetails anti-FCGR3A Antikörper (Biotin)

Produktmerkmale: The 10/78 antibody reacts with NKR-P1A, a 60- kDa homodimer expressed on all natural killer (NK) cells and a small subset of T lymphocytes. The 10/78 antibody competes with the previously described 3.2.3 antibody for binding to the antigen. NKR-P1A is a type-II integral membrane protein with an extracellular C-type lectin domain, which is an NK cell-activating receptor specific for tumor target cells. Many rat dendritic cells have been shown to express NKR-P1A, and a subpopulation of these cells has cytotoxic activity. NKR-P1A has also been detected at low levels on peripheral blood monocytes, and its expression is upregulated in IFN-γ-activated monocytes, specifically in a subpopulation of large monocytes with phagocytic capacity. Furthermore, activated peripheral blood neutrophils may express a low level of NKR-P1A. In the mouse and rat, three members of the NKR-P1 gene family have been identified, but in the human gene family, a single NKR-P1 homologue has been discovered and designated Cd161.

BD Pharmingen™ Biotin Mouse Anti-Rat CD161a - Biotin - Clone 10/78 - Isotype Mouse IgG1, κ - Reactivity Rat - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Referenzen für anti-FCGR3A Antikörper (Biotin) (ABIN2689011)

Trinité, Voisine, Yagita, Josien: "A subset of cytolytic dendritic cells in rat." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 8, pp. 4202-8, (2000) (PubMed).

Scriba, Schneider, Grau, van der Meide, Steiniger: "Rat monocytes up-regulate NKR-P1A and down-modulate CD4 and CD43 during activation in vivo: monocyte subpopulations in normal and IFN-gamma-treated rats." in: Journal of leukocyte biology, Vol. 62, Issue 6, pp. 741-52, (1997) (PubMed).

Kraus, Lambracht, Wonigeit, Hünig: "Negative regulation of rat natural killer cell activity by major histocompatibility complex class I recognition." in: European journal of immunology, Vol. 26, Issue 11, pp. 2582-6, (1997) (PubMed).

Lanier: "Natural killer cells: from no receptors to too many." in: Immunity, Vol. 6, Issue 4, pp. 371-8, (1997) (PubMed).

Ryan, Niemi, Nakamura, Seaman: "NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity." in: The Journal of experimental medicine, Vol. 181, Issue 5, pp. 1911-5, (1995) (PubMed).

Bezouska, Vlahas, Horváth, Jinochová, Fiserová, Giorda, Chambers, Feizi, Pospísil: "Rat natural killer cell antigen, NKR-P1, related to C-type animal lectins is a carbohydrate-binding protein." in: The Journal of biological chemistry, Vol. 269, Issue 24, pp. 16945-52, (1994) (PubMed).

Bezouska, Yuen, OBrien, Childs, Chai, Lawson, Drbal, Fiserová, Pospísil, Feizi: "Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity." in: Nature, Vol. 372, Issue 6502, pp. 150-7, (1994) (PubMed).

Details zu FCGR3A

Target: FCGR3A (Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A))

Andere Bezeichnung: CD161a

Hintergrund: Synonyms: NKR-P1A