CD16 Antikörper (Biotin)

Produktnummer ABIN2689004

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CD16 in FACS. Er zeigt eine Reaktivität gegenüber Rhesusaffen, Cynomolgus und Pavian und wurde in 4+ Publikationen erwähnt.

Kurzübersicht für CD16 Antikörper (Biotin) (ABIN2689004)

Target: CD16

Reaktivität: Rhesusaffen, Cynomolgus, Pavian

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD16 Antikörper ist konjugiert mit Biotin

Applikation: Flow Cytometry (FACS)

Klon: 3G8

Produktdetails anti-CD16 Antikörper (Biotin)

Marke: BD Pharmingen™

Produktmerkmale: Reacts with the 50-65 kDa transmembrane form of IgG Fc (FcγRIII), a human NK-cell-associated antigen. CD16 is expressed on NK cells as well as macrophages and granulocytes. Reports indicate that CD16 plays a role in signal transduction and NK cell activation. CD16 antibody blocks the binding of soluble immune complexes to granulocytes. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of peripheral blood lymphocytes analyzed on a FACScan

BD Pharmingen™ Biotin Mouse Anti-Human CD16 - Biotin - Clone 3G8 - Isotype Mouse IgG1, κ - Reactivity Bab, Cyno, Rhe - 100 Tests

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Probenmenge: 20 μL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Referenzen für anti-CD16 Antikörper (Biotin) (ABIN2689004)

Wirthmueller, Kurosaki, Murakami, Ravetch: "Signal transduction by Fc gamma RIII (CD16) is mediated through the gamma chain." in: The Journal of experimental medicine, Vol. 175, Issue 5, pp. 1381-90, (1992) (PubMed).

Stroncek, Skubitz, Plachta, Shankar, Clay, Herman, Fleit, McCullough: "Alloimmune neonatal neutropenia due to an antibody to the neutrophil Fc-gamma receptor III with maternal deficiency of CD16 antigen." in: Blood, Vol. 77, Issue 7, pp. 1572-80, (1991) (PubMed).

Fleit, Wright, Unkeless: "Human neutrophil Fc gamma receptor distribution and structure." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 79, Issue 10, pp. 3275-9, (1982) (PubMed).

Guesdon, Ternynck, Avrameas: "The use of avidin-biotin interaction in immunoenzymatic techniques." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 27, Issue 8, pp. 1131-9, (1979) (PubMed).

Details zu CD16

Target: CD16

Andere Bezeichnung: CD16

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process