Integrin beta 4 Antikörper

Produktnummer ABIN2688876

Produktdetails anti-Integrin beta 4 Antikörper

Target: Integrin beta 4 (ITGB4)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Integrin beta 4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Marke: BD Pharmingen™

Produktmerkmale: Reacts with CD104, integrin β4 chain, a 205 kDa transmembrane glycoprotein which associates with CD49f (integrin α6 chain) to form the α6/β4 (CD49f/CD104) complex. CD104 is expressed on epithelial cells, Schwann cells, and some tumor cells. The CD49f/CD104 complex is located in the hemidesmosomes of the epidermis, suggesting its role in epidermal cell-basement membrane adhesion. The clone 450-9D recognizes the extracellular domain of human CD104 and is able to block the binding of clone 439-9B (another CD104 clone) to A431 cells. 450-9D is effective in flow cytometry and immunohistochemistry on frozen sections. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of A431, an epidermal carcinoma cell line, analyzed by flow cytometry

BD Pharmingen™ Purified Mouse Anti-Human CD104 - Purified - Clone 450-9D - Isotype Mouse IgG1, λ - Reactivity Hu - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Klon: 450

Isotyp: IgG1 lambda

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-Integrin beta 4 Antikörper (ABIN2688876)

Jones, Kurpakus, Cooper, Quaranta: "A function for the integrin alpha 6 beta 4 in the hemidesmosome." in: Cell regulation, Vol. 2, Issue 6, pp. 427-38, (1991) (PubMed).

Sonnenberg, Calafat, Janssen, Daams, van der Raaij-Helmer, Falcioni, Kennel, Aplin, Baker, Loizidou: "Integrin alpha 6/beta 4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell-basement membrane adhesion." in: The Journal of cell biology, Vol. 113, Issue 4, pp. 907-17, (1991) (PubMed).

Kennel, Epler, Lankford, Foote, Dickas, Canamucio, Cavalierie, Cosimelli, Venturo, Falcioni: "Second generation monoclonal antibodies to the human integrin alpha 6 beta 4." in: Hybridoma, Vol. 9, Issue 3, pp. 243-55, (1990) (PubMed).

Hemler, Crouse, Sonnenberg: "Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines." in: The Journal of biological chemistry, Vol. 264, Issue 11, pp. 6529-35, (1989) (PubMed).

Details zu Integrin beta 4

Target: Integrin beta 4 (ITGB4)

Andere Bezeichnung: CD104 (ITGB4 Produkte)

Hintergrund: Synonyms: Integrin β4 chain

Pathways: Integrin Complex