HIV-1 Tat Antikörper (Biotin)

Produktnummer ABIN2669357

Produktdetails anti-HIV-1 Tat Antikörper (Biotin)

Target: HIV-1 Tat

Reaktivität: Human Immunodeficiency Virus (HIV)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HIV-1 Tat Antikörper ist konjugiert mit Biotin

Applikation: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Spezifität: The antibody detects HIV1 tat protein and GST tat fusion protein. HIVI tat protein in sera or plasma and in cell culture supernatant

Produktmerkmale: Tat is a regulatory protein of HIV-1 virus, well conserved among different isolates. Tat is produced early after infection and it's essential for virus replication and infectivity. Tat protein is also immunogenic and antibodies (Ab) against tat have been found to correlate with delayed disease progression and may exert protective effects by inhibiting both HIV-1 replication and the effects of extracellular tat. Moreover, tat is efficiently taken up by monocyte-derived dendritic cells, promotes their maturation and antigen presenting since it enters the major histocompatibility complex class I pathway. Finally, murine vaccination with a biologically active tat protein has been shown to be safe, immunogenic and elicits anti-tat neutralizing Ab and CTL.

Aufreinigung: Purified by protein A affinity chromatography and conjugated by NHS-biotin.

Immunogen: Purified recombinant protein HIV-I tat expressed in E. coli

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied in PBS and 0.05 % v/v glycerol

Lagerung: 4 °C

Details zu HIV-1 Tat

Target: HIV-1 Tat

Andere Bezeichnung: HIV1 Tat (HIV-1 Tat Produkte)

Substanzklasse: Viral Protein