EZH2 Antikörper (AA 1-370)

Produktnummer ABIN2668956

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch EZH2 in ChIP. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für EZH2 Antikörper (AA 1-370) (ABIN2668956)

Target: EZH2 (Enhancer of Zeste Homolog 2 (EZH2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EZH2 Antikörper ist unkonjugiert

Applikation: Chromatin Immunoprecipitation (ChIP)

Produktdetails anti-EZH2 Antikörper

Bindungsspezifität: AA 1-370

Verwendungszweck: EZH2 antibody (pAb)

Aufreinigung: Protein A Chromatography

Immunogen: This antibody was raised against a recombinant fusion protein corresponding to amino acids 1-370 of mouse EZH2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ChIP: 5 μg per ChIP For EZH2, we also offer AbFlex EZH2 Recombinant Antibody (rAb). For details, see Catalog No. 91159.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 μg/μL

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Lagerung: -20 °C

Informationen zur Lagerung: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Haltbarkeit: 24 months

Details zu EZH2

Target: EZH2 (Enhancer of Zeste Homolog 2 (EZH2))

Andere Bezeichnung: EZH2

Hintergrund: EZH2 - (Enhancer of Zeste homolog 2) is a human homolog of the Drosophila Polycomb-group protein Enhancer of Zeste protein. It contains a SET domain that catalyzes the methylation of histone H3 at lysine 27 (Histone H3 Lys27 monomethylated, dimethylated and trimethylated). Polycomb-group proteins repress gene expression by binding to chromatin and locally altering chromatin structure. EZH2, BMI-1 and Suz12 are present in the PRC2 and PRC3 protein complexes that function as mediators of epigenetic transcriptional silencing. EZH2 associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. EZH2 may play a role in the hematopoietic and central nervous systems. Deregulation of EZH2 is linked to a variety of cancers.

Molekulargewicht: 96 kDa

Gen-ID: 2146

NCBI Accession: NP_031997

Pathways: Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation