Histone H4 Antikörper (H4K20ac)

Produktnummer ABIN2668861

Der Maus Monoklonal anti-Histone H4 Antikörper wird verwendet zum Nachweis von Histone H4 in Proben von Human. Er wurde validiert für ChIP und DB.

Kurzübersicht für Histone H4 Antikörper (H4K20ac) (ABIN2668861)

Target: Histone H4 (HISTH4)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Histone H4 Antikörper ist unkonjugiert

Applikation: Chromatin Immunoprecipitation (ChIP), Dot Blot (DB)

Klon: MABI 0420

Produktdetails anti-Histone H4 Antikörper

Bindungsspezifität: H4K20ac

Verwendungszweck: Histone H4K20ac antibody (mAb) (Clone MABI 0420)

Aufreinigung: Protein G Chromatography

Immunogen: This antibody was raised against a synthetic peptide containing acetyl-lysine 20 of human Histone H4.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: ChIP: 2 - 5 μg per ChIP

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.6 μg/μL

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Lagerung: -20 °C

Informationen zur Lagerung: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Haltbarkeit: 24 months

Details zu Histone H4

Target: Histone H4 (HISTH4)

Andere Bezeichnung: Histone H4

Hintergrund: Histone H4 is one of the core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Histone H1 is a linker histone, present at the interface between the nucleosome core and DNA entry/exit points, it is responsible for establishing higher-order chromatin structure. Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins and the methylation of cytosine residues in the DNA. Reported histone modifications include acetylation, methylation, phosphorylation, ubiquitylation, glycosylation, ADP-ribosylation, carbonylation and SUMOylation, they play a major role in regulating gene expression. Lysine N-e-acetylation is a dynamic, reversible and tightly regulated protein and histone modification that plays a major role in chromatin remodeling and in the regulation of gene expression in various cellular functions. Acetylation of histones is linked to a number of specific processes including transcriptional regulation and genomic organization.

Molekulargewicht: 8 kDa

Gen-ID: 121504

NCBI Accession: NP_778224