RBPJ Antikörper

Produktnummer ABIN2668739

Zitiert in 1 Publikation. Der Ratte Monoklonal anti-RBPJ Antikörper (Klon 7A11) (ABIN2668739) detektiert spezifisch RBPJ in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für RBPJ Antikörper (ABIN2668739)

Target: RBPJ (Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ))

Reaktivität: Human

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser RBPJ Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 7A11

Produktdetails anti-RBPJ Antikörper

Verwendungszweck: RBPJ antibody (mAb) (Clone 7A11)

Aufreinigung: Protein G Chromatography

Immunogen: This antibody was raised against full-length recombinant human RBPJ protein.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: WB: 2 - 4 μg/mL dilution

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 μg/μL

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Lagerung: -20 °C

Informationen zur Lagerung: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Haltbarkeit: 24 months

Referenzen für anti-RBPJ Antikörper (ABIN2668739)

Maier, Santak, Mantik, Grabusic, Kremmer, Hammerschmidt, Kempkes et al.: "A somatic knockout of CBF1 in a human B-cell line reveals that induction of CD21 and CCR7 by EBNA-2 is strictly CBF1 dependent and that downregulation of immunoglobulin M is partially CBF1 ..." in: Journal of virology, Vol. 79, Issue 14, pp. 8784-92, (2005) (PubMed).

Details zu RBPJ

Target: RBPJ (Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ))

Andere Bezeichnung: RBPJ

Hintergrund: RBPJ (Recombination Signal Binding Protein For Immunoglobulin Kappa J Region) is a transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA.

Molekulargewicht: 55 kDa

Gen-ID: 3516

NCBI Accession: NP_005340

Pathways: Notch Signalweg, Stem Cell Maintenance, Smooth Muscle Cell Migration