Retinoic Acid Receptor gamma Antikörper (AA 428-441)

Produktnummer ABIN2668712

Zitiert in 2+ Publikationen. Der Maus Monoklonal anti-Retinoic Acid Receptor gamma Antikörper (Klon 4gamma-7A11) (ABIN2668712) detektiert spezifisch Retinoic Acid Receptor gamma in WB, IHC und SSA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Retinoic Acid Receptor gamma Antikörper (AA 428-441) (ABIN2668712)

Target: Retinoic Acid Receptor gamma (RARG) (Retinoic Acid Receptor, gamma (RARG))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Retinoic Acid Receptor gamma Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Supershift Assay (SSA)

Klon: 4gamma-7A11

Produktdetails anti-Retinoic Acid Receptor gamma Antikörper

Bindungsspezifität: AA 428-441

Verwendungszweck: RAR-gamma antibody (mAb) (Clone 4g-7A11)

Aufreinigung: Protein G Chromatography

Immunogen: This RAR-g antibody was raised against a recombinant protein corresponding to amino acids 428-441 (F-region) of human RARg.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 μg/μL

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Lagerung: -20 °C

Informationen zur Lagerung: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Haltbarkeit: 24 months

Referenzen für anti-Retinoic Acid Receptor gamma Antikörper (ABIN2668712)

Hoftijzer, Liu, Morreau, van Wezel, Pereira, Corssmit, Romijn, Smit: "Retinoic acid receptor and retinoid X receptor subtype expression for the differential diagnosis of thyroid neoplasms." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 160, Issue 4, pp. 631-8, (2009) (PubMed).

Reichrath, Mittmann, Kamradt, Müller: "Expression of retinoid-X receptors (-alpha,-beta,-gamma) and retinoic acid receptors (-alpha,-beta,-gamma) in normal human skin: an immunohistological evaluation." in: The Histochemical journal, Vol. 29, Issue 2, pp. 127-33, (1997) (PubMed).

Details zu Retinoic Acid Receptor gamma

Target: Retinoic Acid Receptor gamma (RARG) (Retinoic Acid Receptor, gamma (RARG))

Andere Bezeichnung: RAR-gamma

Hintergrund: Retinoic acid receptors (RAR) are nuclear receptors that are activated by both all-trans retinoic acid and 9-cis retinoic acid. There are three retinoic acid receptors (RAR), RAR-a, RAR-b and RAR-g. RAR-g has two splice isoforms. RAR-g heterodimerizes with RXR and in the absence of ligand, the RAR/RXR dimer binds to hormone response elements complexed with co-repressor protein. Binding of agonist ligands to RAR results in dissociation of co-repressor and recruitment of coactivator protein which in turn promotes transcription of the downstream target gene into mRNA and eventually protein.

Molekulargewicht: 52 kDa

Gen-ID: 5916

NCBI Accession: NP_000957

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Cell Size