SUV39H1 Antikörper (AA 1-126)

Produktnummer ABIN2668694

Zitiert in 3+ Publikationen. Der Maus Monoklonal anti-SUV39H1 Antikörper (Klon MG44) (ABIN2668694) detektiert spezifisch SUV39H1 in WB, IP, ChIP, IF und ICC. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für SUV39H1 Antikörper (AA 1-126) (ABIN2668694)

Target: SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SUV39H1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Chromatin Immunoprecipitation (ChIP), Immunofluorescence (IF), Immunocytochemistry (ICC)

Klon: MG44

Produktdetails anti-SUV39H1 Antikörper

Bindungsspezifität: AA 1-126

Verwendungszweck: SUV39H1 antibody (mAb) (Clone MG44)

Aufreinigung: Protein G Chromatography

Immunogen: This SUV39H1 antibody was raised against a recombinant protein corresponding to amino acids 1-126 of mouse SUV39H1.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 μg/μL

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Lagerung: -20 °C

Informationen zur Lagerung: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Haltbarkeit: 24 months

Referenzen für anti-SUV39H1 Antikörper (ABIN2668694)

Lee, Hung, Hung, Shieh: "Epidermal growth factor receptor regulates beta-catenin location, stability, and transcriptional activity in oral cancer." in: Molecular cancer, Vol. 9, pp. 64, (2010) (PubMed).

Zhou, Wang, Chen, Carmichael: "On the mechanism of induction of heterochromatin by the RNA-binding protein vigilin." in: RNA (New York, N.Y.), Vol. 14, Issue 9, pp. 1773-81, (2008) (PubMed).

Terada: "Aurora-B/AIM-1 regulates the dynamic behavior of HP1alpha at the G2-M transition." in: Molecular biology of the cell, Vol. 17, Issue 7, pp. 3232-41, (2006) (PubMed).

Details zu SUV39H1

Target: SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))

Andere Bezeichnung: SUV39H1

Hintergrund: SUV39H1 is one of two homologues of the Drosophila Suppressor-of-variegation 3(9) protein (aka Su(var)3-9). SUV39H1 is a SET domain-containing histone methyltransferase specific for lysine 9 of histone H3. Lysine 9 methylation of histone H3 is found at regions of the genome that are transcriptionally silenced, such as centromeres, repetitive elements and inactive genes. H3 lysine 9 methylation is a hallmark of heterochromatin, regions of the genome that are in a tightly compacted state and relatively devoid of gene expression. HP1 proteins recognize and bind lysine 9 methylation and this contributes to maintaining heterochromatin in its compact and inactive state. SUV39H1 also contains a chromodomain, which may bind to lysine 9 methylation and contribute to the regional spreading of lysine 9 methylation and the establishment of heterochromatin over broader domains of the genome.

Molekulargewicht: 50 kDa

Gen-ID: 6839

NCBI Accession: NP_035644