ASCL1 Antikörper

Produktnummer ABIN2668587

Dieser Maus Monoklonal Antikörper detektiert spezifisch ASCL1 in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Maus und Ratte. Es wurde in 3+ Publikationen zitiert.

Kurzübersicht für ASCL1 Antikörper (ABIN2668587)

Target: ASCL1 (Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))

Reaktivität: Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ASCL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: 24B7-2D11-1

Produktdetails anti-ASCL1 Antikörper

Verwendungszweck: MASH1 antibody (mAb) (Clone 24B7.2D11.1)

Aufreinigung: Protein A Chromatography

Immunogen: This MASH1 antibody was raised against a full-length protein corresponding to rat MASH1.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 μg/μL

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Lagerung: -20 °C

Informationen zur Lagerung: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Haltbarkeit: 24 months

Referenzen für anti-ASCL1 Antikörper (ABIN2668587)

Ivaniutsin, Chen, Mason, Price, Pratt: "Adenomatous polyposis coli is required for early events in the normal growth and differentiation of the developing cerebral cortex." in: Neural development, Vol. 4, Issue 1, pp. 3, (2009) (PubMed).

Ralston, Chiriboga, Nonaka: "MASH1: a useful marker in differentiating pulmonary small cell carcinoma from Merkel cell carcinoma." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 21, Issue 11, pp. 1357-62, (2008) (PubMed).

Lo, Johnson, Wuenschell, Saito, Anderson: "Mammalian achaete-scute homolog 1 is transiently expressed by spatially restricted subsets of early neuroepithelial and neural crest cells." in: Genes & development, Vol. 5, Issue 9, pp. 1524-37, (1991) (PubMed).

Details zu ASCL1

Target: ASCL1 (Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))

Andere Bezeichnung: MASH1

Hintergrund: The MASH1 (achaete-scute complex homolog 1 (Drosophila), ASCL1, ASH1, HASH1) gene encodes a protein that is a basic helix-loop-helix transcription factor that may play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcriptional activation by binding to the E box motif.

Molekulargewicht: 34 kDa

Gen-ID: 64186

NCBI Accession: NP_071779

Pathways: Dopaminergic Neurogenesis