Histone H1 Antikörper

Produktnummer ABIN2667975

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Histone H1 in WB, IF und ICC. Es zeigt Reaktivität gegenüber Proben von Human. Es wurde in 2+ Publikationen zitiert.

Kurzübersicht für Histone H1 Antikörper (ABIN2667975)

Target: Histone H1

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Histone H1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Produktdetails anti-Histone H1 Antikörper

Verwendungszweck: Histone H1 antibody (pAb)

Aufreinigung: Unpurified

Immunogen: This Histone H1 antibody was raised against calf thymus histone H1.

Anwendungsinformationen

Applikationshinweise: ICC/IF: 1:500 - 1:1,000 dilution WB: 1:500 - 1:5,000 dilution

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit serum containing 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Lagerung: -20 °C

Informationen zur Lagerung: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Haltbarkeit: 24 months

Referenzen für anti-Histone H1 Antikörper (ABIN2667975)

Li, Wu, Kim, Zhao, Hearn, Zhang, Meistrich, Mills: "Chd5 orchestrates chromatin remodelling during sperm development." in: Nature communications, Vol. 5, pp. 3812, (2014) (PubMed).

Hagarman, Motley, Kristjansdottir, Soloway: "Coordinate regulation of DNA methylation and H3K27me3 in mouse embryonic stem cells." in: PLoS ONE, Vol. 8, Issue 1, pp. e53880, (2013) (PubMed).

Details zu Histone H1

Target: Histone H1

Hintergrund: The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Histone H1 is a linker histone, present at the interface between the nucleosome core and DNA entry/exit points, it is responsible for establishing higher-order chromatin structure. Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins and the methylation of cytosine residues in the DNA. Reported histone modifications include acetylation, methylation, phosphorylation, ubiquitylation, glycosylation, ADP-ribosylation, carbonylation and SUMOylation, they play a major role in regulating gene expression.

Molekulargewicht: 31 kDa

Gen-ID: 3006

NCBI Accession: XP_010816821