Aneurysm, Intracranial Berry 3 Antikörper (AA 22-146)

Produktnummer ABIN2668550

Zitiert in 1 Publikation. Der Kaninchen Polyklonal anti-Aneurysm, Intracranial Berry 3 Antikörper (ABIN2668550) detektiert spezifisch Aneurysm, Intracranial Berry 3 in IHC und WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für Aneurysm, Intracranial Berry 3 Antikörper (AA 22-146) (ABIN2668550)

Target: Aneurysm, Intracranial Berry 3 (ANIB3)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Applikation: Immunohistochemistry (IHC), Western Blotting (WB)

Produktdetails anti-Aneurysm, Intracranial Berry 3 Antikörper

Bindungsspezifität: AA 22-146

Verwendungszweck: AIB3 antibody (pAb)

Aufreinigung: Affinity Purified

Immunogen: This AIB3 antibody was raised against a recombinant protein corresponding to amino acids 22-146 of mouse AIB3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified IgG in 70 mM Tris-HCl ( pH 8), 105 mM NaCl, 70 mM glycine, 30 % glycerol, 0.035 % sodium azide and 0.05 % BSA.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Lagerung: -20 °C

Informationen zur Lagerung: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Haltbarkeit: 24 months

Referenzen für anti-Aneurysm, Intracranial Berry 3 Antikörper (ABIN2668550)

Zhang, Kuang, Liao, Zhou, Xu et al.: "Haploid inactivation of the amplified-in-breast cancer 3 coactivator reduces the inhibitory effect of peroxisome proliferator-activated receptor gamma and retinoid X receptor on cell proliferation ..." in: Cancer research, Vol. 64, Issue 19, pp. 7169-77, (2004) (PubMed).

Details zu Aneurysm, Intracranial Berry 3

Target: Aneurysm, Intracranial Berry 3 (ANIB3)

Andere Bezeichnung: AIB3

Substanzklasse: Chemical

Hintergrund: AIB3 (Amplified in Breast Cancer 3, Nuclear Receptor Coactivator 6, NCoA6) is a chromatin-associated protein that interacts with nuclear hormone receptors (antibodies, kits and proteins) to modify their activity as transcriptional activators. AIB3 / NCoA6 was originally isolated as a ligand-dependent nuclear receptor interacting protein. It is a co-activator that directly binds nuclear receptors and stimulates their transcriptional activity in a hormone-dependent fashion. AIB3 is a multifunctional co-activator necessary for transcriptional activation of a wide spectrum of target genes. AIB3 is involved in growth, development, wound healing and maintenance of energy homeostasis. It can enhance the transcriptional activation of a variety of transcription factors and also associates with a number of important regulators of transcription including CBP and p300. AIB3 / NCoA6 is a component of at least three distinct MLL complexes, suggesting that AIB3 plays a fundamental role in transcriptional activation by modulating chromatin structure through histone methylation. AIB3 may also be involved in the co-activation of the NF-kappa-B pathway. It is amplified and overexpressed in breast, colon and lung cancers. AIB3 function is essential in mammalian development as AIB3 null embryos do not survive. Additionally, AIB null spontaneously undergo apoptosis, indicating that AIB3 has anti-apoptotic and pro-survival functions.

Molekulargewicht: 250 kDa

Gen-ID: 23054

NCBI Accession: NP_062799