AICDA Antikörper (AA 178-198)

Produktnummer ABIN2668532

Zitiert in 1 Publikation. Der Ratte Monoklonal anti-AICDA Antikörper (Klon 328-8b) (ABIN2668532) detektiert spezifisch AICDA in WB und ChIP. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für AICDA Antikörper (AA 178-198) (ABIN2668532)

Target: AICDA (Activation-Induced Cytidine Deaminase (AICDA))

Reaktivität: Human, Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser AICDA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)

Klon: 328-8b

Produktdetails anti-AICDA Antikörper

Bindungsspezifität: AA 178-198

Verwendungszweck: AID antibody (mAb) (Clone 328.8b)

Aufreinigung: Protein G Chromatography

Immunogen: This AID antbody was raised against a peptide corresponding to amino acids 178-198 of human AID.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: WB: 1 - 3 μg/mL dilution

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 μg/μL

Buffer: Purified IgG in 50 mM Tris-HCl ( pH 7.2), 30 % glycerol, and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Lagerung: -20 °C

Informationen zur Lagerung: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Haltbarkeit: 24 months

Referenzen für anti-AICDA Antikörper (ABIN2668532)

Cortizas, Zahn, Hajjar, Patenaude, Di Noia, Verdun: "Alternative end-joining and classical nonhomologous end-joining pathways repair different types of double-strand breaks during class-switch recombination." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 11, pp. 5751-63, (2013) (PubMed).

Details zu AICDA

Target: AICDA (Activation-Induced Cytidine Deaminase (AICDA))

Andere Bezeichnung: AID

Hintergrund: AID (Activation-induced cytidine deaminase, AICDA) is a member of the cytidine and deoxycytidylate deaminase family. It acts act as a single-strand DNA deaminase involved in somatic hypermutation, gene conversion and class-switch recombination in developing B-cells and is necessary for efficient antibody responses. It has also been implicated in active DNA demethylation, as deamination of methylcytosine yields thymine, which is read as a mismatch and is replaced by DNA damage repair enzymes.

Molekulargewicht: 24 kDa

Gen-ID: 57379

NCBI Accession: NP_065712

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Production of Molecular Mediator of Immune Response