IKZF3 Antikörper

Produktnummer ABIN2666385

Produktdetails anti-IKZF3 Antikörper

Target: IKZF3 (IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3))

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IKZF3 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Keine Kreuzreaktivität: Maus

Klon: 8B2

Isotyp: IgG1 kappa, IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: phosphate-buffered solution, pH 7.2, containing 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Upon receipt, store undiluted between 2°C and 8°C.

Details zu IKZF3

Target: IKZF3 (IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3))

Andere Bezeichnung: Aiolos (IKZF3 Produkte)

Synonyme: AIO antikoerper, AIOLOS antikoerper, ZNFN1A3 antikoerper, aio antikoerper, aiolos antikoerper, znfn1a3 antikoerper, IKZF3 antikoerper, 5830411O07Rik antikoerper, Aiolos antikoerper, Zfpn1a3 antikoerper, Znfn1a3 antikoerper, IKAROS family zinc finger 3 antikoerper, IKAROS family zinc finger 3 L homeolog antikoerper, IKZF3 antikoerper, ikzf3.L antikoerper, Ikzf3 antikoerper

Hintergrund: Aiolos, an Ikaros family member, is also known as Izkf3. It has a molecular weight of 58 kD and shows 70 % homology to the Ikaros isoform, Ik-1, particularly in the DNA binding and C-terminal domains. Aiolos can form a heteromer with Ikaros or exist as a homodimer. The homomeric complex is a potent transcriptional activator. Unlike Ikaros, Aiolos is expressed in late fetal thymus and adult lymphoid organs. Among the adult hematopoietic progenitors, Aiolos is expressed at low levels in mulitpotent but not in pluripotent stem cells. When these multipotent progenitors become more restricted to T and B lymphoid pathways there is an upregulation in Aiolos expression. The highest expression of Aiolos is detected in the spleen (especially in B-cells) followed by thymus and bone marrow, and cannot be detected in the non-lymphoid organs. Aiolos plays an important role in lymphocyte proliferation and differentiation.