TIMP1 Antikörper

Produktnummer ABIN2666373

Dieses Maus Monoklonal-Antikörper erkennt spezifisch TIMP1 in FACS. Er zeigt eine Reaktivität gegenüber Human und Affe.

Kurzübersicht für TIMP1 Antikörper (ABIN2666373)

Target: TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))

Reaktivität: Human, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TIMP1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: F31P2A5

Produktdetails anti-TIMP1 Antikörper

Aufreinigung: The antibody was purified by affinity chromatography.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide at 0.5 mg/mL.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Upon receipt, store undiluted between 2°C and 8°C.

Details zu TIMP1

Target: TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))

Andere Bezeichnung: TIMP-1

Hintergrund: TIMP-1 (Tissue inhibitor of metalloproteinase 1) is a glycoprotein that belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain, predicted molecular weight 23 kD. TIMP-1 forms complexes with matrix metalloproteinases (MMPs) and inhibits the proteolytic activity of these enzymes. High levels TIMP-1 protein has been found in several types of cancers including breast cancer and this increase associated with a poor patient prognosis. TIMP-1 has also been implicated in the inhibition of apoptosis, promotion of growth, and process of angiogenesis. TIMP-1 may be useful as a prognostic marker in combination with urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1). Clone F31P2A5 has been shown to be useful for western blotting, immunohistochemistry and ELISA of human and monkey TIMP-1.