Cathelicidin Antikörper (AA 115-121)

Produktnummer ABIN2666321

Produktdetails anti-Cathelicidin Antikörper

Target: Cathelicidin (CAMP) (Cathelicidin Antimicrobial Peptide (CAMP))

Bindungsspezifität: AA 115-121

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Cathelicidin Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Aufreinigung: The antibody was purified by affinity chromatography.

Klon: H7

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: phosphate-buffered solution, pH 7.2, 0.09 % Sodium azide.

Lagerung: 4 °C

Informationen zur Lagerung: Upon receipt, store undiluted between 2°C and 8°C.

Details zu Cathelicidin

Target: Cathelicidin (CAMP) (Cathelicidin Antimicrobial Peptide (CAMP))

Andere Bezeichnung: CAP-18 (CAMP Produkte)

Synonyme: CAP-18 antikoerper, CAP18 antikoerper, CRAMP antikoerper, FALL-39 antikoerper, FALL39 antikoerper, LL37 antikoerper, CATH-2 antikoerper, Cnlp antikoerper, Cramp antikoerper, MCLP antikoerper, CATH-B1 antikoerper, CATHB1 antikoerper, CATHL2 antikoerper, CATHL7 antikoerper, CAP11 antikoerper, cathelicidin antimicrobial peptide antikoerper, CAMP antikoerper, LOC100136187 antikoerper, LOC100136439 antikoerper, Camp antikoerper

Hintergrund: Antimicrobial peptides (AMP) are effector molecules of the innate immune system with direct antimicrobioal and immunomodulatory effects. AMP are produced by epithelial and professional host defense cells such as macrophages or neutrophils. AMP directly inactivate microorganisms and, in addition, have diverse activities on various cell types. In mammals, peptides of the defensin and the cathelicidin families are found. hCAP-18 is the only cathelicidin present in humans. hCAP-18 is a 170 amino acid cathelicidin anti-microbial precursor protein that is proteolytically processed to yield the antibacterial peptide LL-37. The precursor hCAP-18 is found in the specific granules of neutrophils and is expressed in many immune and epithelial cells. Cathelicidin has an established role in host defense. In addition to their direct antimicrobial function, cathelicidin peptides are involved in the modulation of repair and tissue homeostasis, epithelial wound healing, chemoattraction of immune cells, and release of inflammatory mediators from epithelial cells. Recent studies also found that LL-37 significantly regulates endocytic capacity, modifies expression of phagocytic receptors, increases secretion of Th1-inducing cytokines of dendritic cells (DC) generated from blood monocytes, and modulates the response of monocytes and DC to toll like receptor (TLR)-ligands. Moreover LL-37 also modulates the response of neutrophils to bacterial activation.

Pathways: Cellular Response to Molecule of Bacterial Origin