BCL11B Antikörper
Kurzübersicht für BCL11B Antikörper (ABIN2666299)
Target
Alle BCL11B Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Kreuzreaktivität
- Maus, Zebrafisch
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Kreuzreaktivität (Details)
- Mouse, Zebrafish
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Aufreinigung
- Protein G affinity purified.
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Isotyp
- IgG
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Buffer
- Hepes-buffered solution, pH 7.5, 0.02 % Sodium azide .
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Lagerung
- 4 °C
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Informationen zur Lagerung
- Upon receipt, store undiluted between 2°C and 8°C.
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- BCL11B (B-Cell CLL/lymphoma 11B (Zinc Finger Protein) (BCL11B))
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Andere Bezeichnung
- Bcl11b
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Hintergrund
- The transcription factor Bcl11b is expressed in thymus, mainly T cells. It is indispensable for T lineage development. When Bcl11b was deleted, T cells from all developmental stages acquired NK cell properties and concomitantly lost or decreased T cell-associated gene expression. These induced T-to-natural killer (ITNK) cells, which were morphologically and genetically similar to conventional NK cells, killed tumor cells in vitro, and effectively prevented tumor metastasis in vivo. Therefore, ITNKs may represent a new cell source for cell-based therapies.
Target
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