IL-33 Antikörper (Ser109)

Produktnummer ABIN2665498

Der Ziege Polyklonal Anti-IL-33-Antikörper wurde für WB, IHC, IP und IF validiert. Er ist geeignet, IL-33 in Proben von Maus und Ratte zu detektieren.

Kurzübersicht für IL-33 Antikörper (Ser109) (ABIN2665498)

Target: IL-33 (IL33) (Interleukin 33 (IL33))

Reaktivität: Maus, Ratte

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser IL-33 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Klon: Poly5165

Produktdetails anti-IL-33 Antikörper

Bindungsspezifität: Ser109

Kreuzreaktivität: Ratte (Rattus)

Aufreinigung: The antibody was purified by antigen affinity chromatography.

Immunogen: Ser109-Isoleucin266 (Accession# NM_133775) was expressed in E. coli.

Isotyp: Ig Fraction, IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu IL-33

Target: IL-33 (IL33) (Interleukin 33 (IL33))

Andere Bezeichnung: IL-33

Hintergrund: IL-33 belongs to the IL-1 family and is closely related in structure to IL-18 and IL-1b. IL-33, IL-1b, and IL-18 are synthesized as biologically inactive precursor and are cleaved by the enzyme caspase-1 to be secreted as active mature forms. IL-33 stimulates target cells by binding to the IL-1R/TLR superfamily member ST2 and subsequently activates NF-κB and MAPK pathways via identical signalling events to those observed for IL-1b. In addition, IL-33 is a nuclear factor (NF-HEV) abundantly expressed in high endothelial venules from lymphoid organs that associates with chromatin and exhibits transcriptional regulatory properties.

Pathways: Production of Molecular Mediator of Immune Response