mMCP-8 Antikörper

Produktnummer ABIN2665274

Dieses Anti--Antikörper ist ein Ratte Monoklonal-Antikörper zur Detektion von in FACS und IF. Geeignet für Maus.

Kurzübersicht für mMCP-8 Antikörper (ABIN2665274)

Target: mMCP-8

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF)

Klon: TUG8

Produktdetails

Aufreinigung: The antibody was purified by affinity chromatography.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Antigendetails

Target: mMCP-8

Hintergrund: MMCP-8 and its rat homologues, rMCP-8, -9, and -10, form a new group of mast cell/basophil proteases, which are more closely related to the T-cell granzymes and neutrophil cathepsin G than to the mast cell tryptases and chymases. mMCP-8 showed a high degree of homology with mouse granzyme B in the critical regions for determining substrate cleavage specificity. It preferentially cleaves after Asp residues. mMCP-8 mRNA is highly expressed in a mouse connective tissue MC-like tumor line. However, it could not be detected in mouse liver, intestine, lung or ears, indicating very low expression in normal tissues. A strong increase in mMCP-8 levels in the lungs can be detected in infected animals.