IRF6 Antikörper

Produktnummer ABIN2665207

Der Maus Monoklonal Anti-IRF6-Antikörper wurde für WB validiert. Er ist geeignet, IRF6 in Proben von Human zu detektieren.

Kurzübersicht für IRF6 Antikörper (ABIN2665207)

Target: IRF6 (Interferon Regulatory Factor 6 (IRF6))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IRF6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 14B2C16

Produktdetails anti-IRF6 Antikörper

Aufreinigung: The antibody was purified by affinity chromatography.

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu IRF6

Target: IRF6 (Interferon Regulatory Factor 6 (IRF6))

Andere Bezeichnung: IRF6

Hintergrund: IRF6 is a member of the IRF family of transcription factors, which are based on the presence of the conserved IRF tryptophan pentad repeat DNA-binding domain. Unlike other IRF transcription factors, IRF6 is not involved in the expression of interferon genes and doesn't seem to be involved in innate immunity. Data suggests that IRF6 is necessary for appropriate epidermal differentiation and development. Mutations of IRF6 are associated with human craniofacial developmental defects such as cleft lip, palate, tooth agenesis, Van der Woude syndrome, and popliteal pterygium syndrome. IRF6-deficient mice display severe morphological defects in skin and limbs, and result in perinatal lethality as well.