IRF2 Antikörper

Produktnummer ABIN2665203

Produktdetails anti-IRF2 Antikörper

Target: IRF2 (Interferon Regulatory Factor 2 (IRF2))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IRF2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: The antibody was purified by affinity chromatography.

Klon: 13B2A38

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu IRF2

Target: IRF2 (Interferon Regulatory Factor 2 (IRF2))

Andere Bezeichnung: IRF2 (IRF2 Produkte)

Synonyme: IRF-2 antikoerper, 9830146E22Rik antikoerper, AI646973 antikoerper, Irf-2 antikoerper, irf2b antikoerper, zgc:103451 antikoerper, irf-2 antikoerper, wu:fc74h04 antikoerper, zgc:76951 antikoerper, interferon regulatory factor 2 antikoerper, interferon regulatory factor 2 L homeolog antikoerper, interferon regulatory factor 2a antikoerper, IRF2 antikoerper, Irf2 antikoerper, irf2 antikoerper, irf2.L antikoerper, irf2a antikoerper

Hintergrund: IRF2 is a member of the IRF family of transcription factors, mainly functioning as a transcriptional repressor. It binds to the interferon-sensitive response elements (ISREs) and competes for binding sites with the other IRF transcription factors, such as IRF1 and IRF9. Mice deficient in IRF2 spontaneously develop skin inflammation due to excessive activation of CD8+ T lymphocytes. Further, the severely reduced number of mature NK cells in IRF2-deficient mice suggests that IRF2 is required for normal NK cell development. IRF2 contains a latent activation domain that can act as a transcriptional activator and has been revealed to positively regulate Histone H4 and VCAM-1 gene expression.