IB-alpha Antikörper

Produktnummer ABIN2665062

Dieser Maus Monoklonal Antikörper detektiert spezifisch IB-alpha in FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für IB-alpha Antikörper (ABIN2665062)

Target: IB-alpha

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Applikation: Flow Cytometry (FACS)

Klon: 3D6C02

Produktdetails

Kreuzreaktivität: Maus

Kreuzreaktivität (Details): Weakly reacts with mouse

Aufreinigung: The antibody was purified by affinity chromatography.

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Antigendetails

Target: IB-alpha

Hintergrund: IκB-α is an inhibitory protein that binds to the NF-κB complex and retains this complex in the cytoplasm where it cannot activate transcription. Upon cellular stimulation, the IκB proteins are phosphorylated and degraded via the ubiquitin pathway allowing for nuclear translocation of NF-κB. The NF-κB complex can then bind DNA to activate gene expression of multiple proteins involved in inflammation, cellular proliferation, differentiation, and apoptosis.