CD8 Antikörper

Produktnummer ABIN2664826

Der Maus Monoklonal Anti-CD8-Antikörper wurde für BCA und DNA Mic validiert. Er ist geeignet, CD8 in Proben von Human zu detektieren.

Kurzübersicht für CD8 Antikörper (ABIN2664826)

Target: CD8

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD8 Antikörper ist unkonjugiert

Applikation: Biochemical Assay (BCA), DNA Microscopy (DNA Mic)

Klon: SK1

Produktdetails anti-CD8 Antikörper

Kreuzreaktivität: Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops), Schimpanse, Cynomolgus, Pigtailed Macaque, Rhesusaffen, Sooty mangabey (Cercocebus atys), Green Monkey (Chlorocebus sabaeus)

Aufreinigung: The antibody was purified by affinity chromatography.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and EDTA.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu CD8

Target: CD8

Andere Bezeichnung: CD8

Hintergrund: CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.