CD45RB Antikörper

Produktnummer ABIN2664723

Dieses Ratte Monoklonal-Antikörper erkennt spezifisch CD45RB in FACS und ICFC. Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für CD45RB Antikörper (ABIN2664723)

Target: CD45RB

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CD45RB Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Intracellular Flow Cytometry (ICFC)

Klon: C363-16A

Produktdetails anti-CD45RB Antikörper

Aufreinigung: The antibody was purified by affinity chromatography.

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu CD45RB

Target: CD45RB

Andere Bezeichnung: CD45RB

Hintergrund: CD45RB is an isoform of CD45 with exon 5 splicing (encodes B determinant). It is a 220 kD glycoprotein expressed on peripheral B cells, naive T cells, thymocytes, weakly on macrophages, and dendritic cells. It plays a critical role in TCR and BCR signaling. As T cells become activated and progress from naive to memory cells, CD45RB expression is downregulated. Additionally, functionally distinct CD4+ T cell subsets, which secrete differing cytokine profiles, can be separated by CD45RB intensity. The primary ligands for CD45 are galectin-1, CD2, CD3, CD4 and Thy-1.