2B4 Antikörper

Produktnummer ABIN2664430

Der Maus Monoklonal Anti-2B4-Antikörper wurde für FACS und DNA Mic validiert. Er ist geeignet, 2B4 in Proben von Human zu detektieren.

Kurzübersicht für 2B4 Antikörper (ABIN2664430)

Target: 2B4 (CD244) (Natural Killer Cell Receptor 2B4 (CD244))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser 2B4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), DNA Microscopy (DNA Mic)

Klon: C1-7

Produktdetails anti-2B4 Antikörper

Aufreinigung: The antibody was purified by affinity chromatography.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu 2B4

Target: 2B4 (CD244) (Natural Killer Cell Receptor 2B4 (CD244))

Andere Bezeichnung: CD244

Hintergrund: CD244, known as 2B4, is a 38 kD type I transmembrane protein. It is a member of the CD2 subset of the immunoglobulin superfamily (IgSF) molecules. CD244 is expressed on NK cells, a subset of T cells (including majority of CD8+ T cells and γ/δ T cells), monocytes, basophils, and eosinophils. CD48 is the ligand of CD244. It has been reported that ligation of human CD244 results in enhanced NK cell cytotoxicity and cytokine production. Recent studies have shown that human CD244, like murine CD244, has both activating and inhibitory functions, which are dependent on the density of surface 2B4 expression, degree of ligation, and the level of the adaptor molecule SAP expression.