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- Target Alle CCR2 Antikörper anzeigen
- CCR2 (Chemokine (C-C Motif) Receptor 2 (CCR2))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser CCR2 Antikörper ist unkonjugiert
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Applikation
- Intracellular Flow Cytometry (ICFC)
- Aufreinigung
- The antibody was purified by affinity chromatography.
- Klon
- K036C2
- Isotyp
- IgG2a kappa
- Top Product
- Discover our top product CCR2 Primärantikörper
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anti-Chemokine (C-C Motif) Receptor 2 (CCR2) antibody
CCR2 Reaktivität: Human WB, ELISA, FACS Wirt: Maus Monoclonal 3B6B1 unconjugated
anti-Chemokine (C-C Motif) Receptor 2 (CCR2) (N-Term) antibodyCCR2 Reaktivität: Human WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 2 (CCR2) antibodyCCR2 Reaktivität: Human, Maus, Ratte, Hund IHC (p), IF (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 2 (CCR2) (AA 301-373) antibodyCCR2 Reaktivität: Human, Maus, Ratte ELISA, FACS, IHC (p), ICC, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 2 (CCR2) (N-Term) antibodyCCR2 Reaktivität: Human, Affe IHC, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 2 (CCR2) (AA 1-42) antibodyCCR2 Reaktivität: Human WB, ELISA Wirt: Maus Monoclonal 4D12 unconjugated
anti-Chemokine (C-C Motif) Receptor 2 (CCR2) antibodyCCR2 Reaktivität: Human WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 2 (CCR2) (AA 315-374) antibodyCCR2 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 2 (CCR2) antibody (HRP)CCR2 Reaktivität: Human WB, IHC Wirt: Kaninchen Polyclonal HRP
anti-Chemokine (C-C Motif) Receptor 2 (CCR2) antibody (FITC)CCR2 Reaktivität: Human WB, IHC Wirt: Kaninchen Polyclonal FITC
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 0.5 mg/mL
- Buffer
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- Target
- CCR2 (Chemokine (C-C Motif) Receptor 2 (CCR2))
- Andere Bezeichnung
- CD192 (CCR2 Produkte)
- Hintergrund
- CCR2 is a chemokine receptor that binds monocyte chemoattractant proteins (MCP-1, 2, 3 and 4). Two spliced variants were initially described for CCR2 (CCR2A and CCR2B). These variants differ in their terminal carboxyl tails. Monocyte adhesion to the arterial endothelium and subsequent migration into the intima are central events in the pathogenesis of atherosclerosis. CCR2 and MCP-1 have been associated to atherosclerotic plaques. MCP-1 is induced by modified-LDL in endothelial cells and may trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Local overexpression of MCP-1 at vessel walls induces infiltration of macrophages and formation of atherosclerotic lesions. Obesity induces an inflammatory state that is implicated in many clinically important complications, including insulin resistance, diabetes, atherosclerosis, and non-alcoholic fatty liver disease. CCR2 influences the development of obesity and associated adipose tissue inflammation.
- Pathways
- cAMP Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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