PRDM1 Antikörper

Produktnummer ABIN2664076

Produktdetails anti-PRDM1 Antikörper

Target: PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PRDM1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Kreuzreaktivität: Maus

Aufreinigung: The antibody was purified by affinity chromatography.

Klon: ROS195G

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu PRDM1

Target: PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))

Andere Bezeichnung: Blimp-1 (PRDM1 Produkte)

Hintergrund: Blimp-1 is a 98 Kd protein containing five Kuppel-type zinc finger domains that confer sequence specific DNA binding. It has been postulated to be a master regulator of terminal B cell differentiation. In the BCL-1 lymphoma model of differentiation from mature B cells to plasma cells, ectopic expression of Blimp-1 is sufficient to cause terminal differentiation manifested by loss of surface immunoglobulin, IgM secretion, expression of syndecan-1 and cessation of cell division. Recently, it is reported that Blimp-1 is also involved in T cell differentiation and T cell homeostasis and suppression of IL-2 production.

Pathways: Regulation of Muscle Cell Differentiation