ZBTB16 Antikörper (PE)

Produktnummer ABIN2662834

Produktdetails anti-ZBTB16 Antikörper (PE)

Target: ZBTB16 (Zinc Finger and BTB Domain Containing 16 (ZBTB16))

Reaktivität: Maus

Wirt: Armenischer Hamster

Klonalität: Monoklonal

Konjugat: Dieser ZBTB16 Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Aufreinigung: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Klon: 9E12

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from prolonged exposure to light. Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu ZBTB16

Target: ZBTB16 (Zinc Finger and BTB Domain Containing 16 (ZBTB16))

Andere Bezeichnung: PLZF (ZBTB16 Produkte)

Synonyme: PLZF antikoerper, ZNF145 antikoerper, ZGC:55675 antikoerper, AI467657 antikoerper, Zfp145 antikoerper, lu antikoerper, Lx antikoerper, Plzf antikoerper, Znf145 antikoerper, wu:fb93g12 antikoerper, wu:fc07c10 antikoerper, zbtb16 antikoerper, zgc:55675 antikoerper, zinc finger and BTB domain containing 16 antikoerper, zinc finger and BTB domain containing 32 antikoerper, zinc finger and BTB domain containing 16a antikoerper, ZBTB16 antikoerper, ZBTB32 antikoerper, Zbtb16 antikoerper, zbtb16a antikoerper

Hintergrund: PLZF (promyelocytic leukemia zinc finger), also known as Zbtb16, Zinc finger and BTB domain-containing protein 16, Zfp145, is a member of the BTB-POZ family of transcription factors. It was first identified in a patient with acute promyelocytic leukemia, where a reciprocal chromosomal translocation t(11,17)(q23,q21) resulted in a fusion with RARA gene encoding retinoic acid receptor alpha. Expression of this transcriptional repressor in immune cells differs between human and mouse. In humans, PLZF is expressed in CD34+ progenitor cells and in primitive multipotent hematopoietic cell lines, NK cells, γ/δ T cells, CD4+ and CD8+ T cells. It is also expressed in MR1-specific mucosal-associated invariant T cells as well as in MHC class II-restricted T cells that develop via a thymocyte-thymocyte interaction. PLZF is involved in NK cell function, cellular quiescence, and growth suppression. It also inhibits gene expression induced by retinoic acid receptor. In mice, PLZF is highly expressed in immature CD1d-resricted invariant NKT (iNKT) cells, a subset of γ/δ (Vg1.1+Vd6.3+) T cells, and non-invariant CD1d-restricted T cells. PLZF exists as a homodimer or in complex with PLZP, and has been shown to be involved in the development of NKT cells. It is also reported to be expressed in embryonic tissues, giving rise to hematopoietic progenitors.

Pathways: Positive Regulation of fat Cell Differentiation