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ISM1 Antikörper (PE)

ISM1 Reaktivität: Maus FACS Wirt: Ratte Monoclonal B054B6 PE
Produktnummer ABIN2662774
  • Target Alle ISM1 Antikörper anzeigen
    ISM1 (Isthmin 1 (ISM1))
    Reaktivität
    • 24
    • 18
    Maus
    Wirt
    • 24
    • 1
    Ratte
    Klonalität
    • 24
    • 1
    Monoklonal
    Konjugat
    • 8
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ISM1 Antikörper ist konjugiert mit PE
    Applikation
    • 16
    • 14
    • 13
    • 3
    • 1
    Flow Cytometry (FACS)
    Aufreinigung
    The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
    Klon
    B054B6
    Isotyp
    IgG2a kappa
    Top Product
    Discover our top product ISM1 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.2 mg/mL
    Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Protect from prolonged exposure to light. Do not freeze.
    Lagerung
    4 °C
    Informationen zur Lagerung
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Target
    ISM1 (Isthmin 1 (ISM1))
    Andere Bezeichnung
    Isthmin-1 (ISM1 Produkte)
    Synonyme
    5430433G21Rik antikoerper, Ism antikoerper, C20orf82 antikoerper, ISM antikoerper, Isthmin antikoerper, bA149I18.1 antikoerper, dJ1077I2.1 antikoerper, ism antikoerper, xIsm antikoerper, isthmin 1 antikoerper, isthmin 1, angiogenesis inhibitor antikoerper, isthmin 1, angiogenesis inhibitor L homeolog antikoerper, ism1 antikoerper, Ism1 antikoerper, ISM1 antikoerper, ism1.L antikoerper
    Hintergrund
    Isthmin is a secreted protein, and it was initially identified in the Xenopus midbrain-hindbrain organizer (MHB) or isthmus organizer, where it is highly expressed. The MHB is an important signaling center in vertebrates and regulates the polarized morphological differentiation of the adjacent tectum and cerebellum. Mouse Isthmin is a 454 amino acid protein containing a Thrombospondin Type 1 Repeat (TSR) domain in the central region and an Adhesion-associated domain in MUC4 and Other Proteins (AMOP) domain at the C-terminal. The TSR domains are highly conserved with 98 % identity between mouse and human, 87-88 % identity between mouse and Xenopus. The C-terminal AMOP domains are also highly conserved with 99 % identity between mouse and human, 91 % identity between mouse and Xenopus. Mouse isthmin nucleotide sequence is similar to the human chromosome 20 open reading frame 82 (C20orf82). The Ism1 gene is conserved in human, chimpanzee, dog, cow, chicken, and zebrafish. Isthmin has angiostatic activity in vitro and in vivo. Isthmin inhibits EC capillary network formation mainly by interfering with the early stages of in vitro angiogenesis on matrigel. Isthmin inhibits VEGF-induced EC proliferation and induces apoptosis in the presence of VEGF. Overexpression of isthmin in B16 melanoma inhibits tumor growth and tumor angiogenesis in mice. Knockdown of isthmin in zebrafish embryos leads to abnormal intersegmental vessel (ISV) formation in the trunk.
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