IL16 Antikörper (Interleukin 16) (AA 615-630) (PE)

Details for Product anti-IL16 Antibody No. ABIN2662757, Anbieter: Anmelden zum Anzeigen
Antigen
  • IL16
  • LCF
  • NIL16
  • PRIL16
  • prIL-16
  • mKIAA4048
  • IL-16
  • interleukin 16
  • IL16
  • Il16
Epitop
AA 615-630
18
17
8
8
7
7
7
5
5
3
3
3
3
2
2
1
1
1
1
1
Reaktivität
Human
185
38
27
3
2
2
1
1
1
Wirt
Maus
121
79
2
2
1
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser IL16 Antikörper ist konjugiert mit PE
11
5
3
2
2
2
2
2
2
2
2
2
1
1
Applikation
Flow Cytometry (FACS)
128
107
39
24
19
18
17
15
14
6
5
3
3
2
2
2
2
1
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Immunogen AA 615-630 (RRKSLQSKETTAAGDS) of IL-16
Klon 14-1
Isotyp IgG2a
Kreuzreaktivität Maus
Reinigung The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Andere Bezeichnung IL-16 (IL16 Antibody Abstract)
Hintergrund Interleukin-16 is a proinflammatory cytokine synthesized as a 68 kD precursor molecule (pro-IL-16). After cleavage of pro-IL-16 by caspase-3, IL-16 is released as a 12 kD protein, but its biologic activities are exerted by a tetramer. IL-16 is a chemoattractant for CD4+ T cells, monocytes, and eosinophils. On T cells, IL-16 upregulates CD25 and class II expression, and also inhibits HIV-1 replication in vitro by repressing the transcription of the HIV-1 long terminal repeat. IL-16 is expressed by lymphocytes, macrophages, eosinophils, mast cells, epithelial cells, and fibroblasts. CD4 and CD9 are the receptors of IL-16.
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Protect from prolonged exposure to light. Do not freeze.
Lagerung 4 °C
Informationen zur Lagerung The antibody solution should be stored undiluted between 2°C and 8°C.
Bilder des Herstellers
Flow Cytometry (FACS) image for anti-Interleukin 16 (IL16) (AA 615-630) antibody (PE) (ABIN2662757) anti-Interleukin 16 (IL16) (AA 615-630) antibody (PE)
Flow Cytometry (FACS) image for anti-Interleukin 16 (IL16) (AA 615-630) antibody (PE) (ABIN2662757) anti-Interleukin 16 (IL16) (AA 615-630) antibody (PE) (Image 2)
Allgemeine Veröffentlichungen Bellon, Baydoun, Yao, Nicot: "HTLV-I Tax-dependent and -independent events associated with immortalization of human primary T lymphocytes." in: Blood, Vol. 115, Issue 12, pp. 2441-8, 2010 (PubMed).

Cruikshank, Little: "lnterleukin-16: the ins and outs of regulating T-cell activation." in: Critical reviews in immunology, Vol. 28, Issue 6, pp. 467-83, 2009 (PubMed).

Rofani, Luchetti, Testa, Lasorella, Isacchi, Bottazzo, Berardi: "IL-16 can synergize with early acting cytokines to expand ex vivo CD34+ isolated from cord blood." in: Stem cells and development, Vol. 18, Issue 4, pp. 671-82, 2009 (PubMed).

Gu, Lewis, Deere, Groome, Wang: "Elevated maternal IL-16 levels, enhanced IL-16 expressions in endothelium and leukocytes, and increased IL-16 production by placental trophoblasts in women with preeclampsia." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 6, pp. 4418-22, 2008 (PubMed).

McFadden, Morgan, Rahangdale, Green, Yamasaki, Center, Cruikshank: "Preferential migration of T regulatory cells induced by IL-16." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 10, pp. 6439-45, 2007 (PubMed).

Qi, Wang, Mandadi, Tanaka, Roufogalis, Madigan, Lai, Yan, Chong, Stevens, Krilis: "Human and mouse mast cells use the tetraspanin CD9 as an alternate interleukin-16 receptor." in: Blood, Vol. 107, Issue 1, pp. 135-42, 2005 (PubMed).

Ren, Zhan, Martens, Lee, Center, Hanson, Kornfeld: "Pro-IL-16 regulation in activated murine CD4+ lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 5, pp. 2738-45, 2005 (PubMed).

Stoitzner, Ratzinger, Koch, Janke, Schöller, Kaser, Tilg, Cruikshank, Fritsch, Romani: "Interleukin-16 supports the migration of Langerhans cells, partly in a CD4-independent way." in: The Journal of investigative dermatology, Vol. 116, Issue 5, pp. 641-9, 2001 (PubMed).

Chupp, Wright, Wu, Vallen-Mashikian, Cruikshank, Center, Kornfeld, Berman: "Tissue and T cell distribution of precursor and mature IL-16." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 6, pp. 3114-9, 1998 (PubMed).

Keane, Nicoll, Kim, Wu, Cruikshank, Brazer, Natke, Zhang, Center, Kornfeld: "Conservation of structure and function between human and murine IL-16." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 12, pp. 5945-54, 1998 (PubMed).

Cruikshank, Center, Nisar, Wu, Natke, Theodore, Kornfeld: "Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 11, pp. 5109-13, 1994 (PubMed).

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