CXCL9 Antikörper (PE)

Produktnummer ABIN2662706

Dieses Anti-CXCL9-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von CXCL9 in FACS. Geeignet für Human.

Kurzübersicht für CXCL9 Antikörper (PE) (ABIN2662706)

Target: CXCL9 (gamma-Interferon-Induced Monokine (CXCL9))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CXCL9 Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Klon: J1015E10

Produktdetails anti-CXCL9 Antikörper (PE)

Aufreinigung: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from prolonged exposure to light. Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu CXCL9

Target: CXCL9 (gamma-Interferon-Induced Monokine (CXCL9))

Andere Bezeichnung: CXCL9

Hintergrund: Chemokine (C-X-C motif) ligand 9 (CXCL9), also known as monokine induced by gamma interferon (MIG), is a small cytokine belonging to the non-ELR (lacking a Glu-Leu-Arg motif in the N-terminal region) motif CXC chemokines. CXCL9 is one of the ligands to share its receptor, CXCR3, with other two CXC chemokine family members, CXCL10 and CXCL11, through different binding fashions. The rank order of binding affinity is CXCL11>CXCL10>CXCL9. Some studies have revealed that these ligands have redundant functions in vivo, other studies have demonstrated that the three CXCR3 ligands can collaborate and even compete with each other. CXCL9 is mainly produced by activated macrophages and some cancer cells. Functioning as a chemoattractant, CXCL9 attracts CXCR3-expressing cells (such as a subset of circulating T cells, B cells, and natural killer cells) into inflammatory sites. Like other chemokines, CXCL9 is also able to elicit intracellular calcium flux and activate PI3K and MAPK. It participates in multiple immune and inflammatory responses by affecting cell growth, movement, or activation.