LY75/DEC-205 Antikörper (PE)

Produktnummer ABIN2662527

Dieses Maus Monoklonal-Antikörper erkennt spezifisch LY75/DEC-205 in FACS. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für LY75/DEC-205 Antikörper (PE) (ABIN2662527)

Target: LY75/DEC-205 (LY75) (Lymphocyte Antigen 75 (LY75))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LY75/DEC-205 Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Klon: HD83

Produktdetails anti-LY75/DEC-205 Antikörper (PE)

Kreuzreaktivität: Affe

Aufreinigung: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from prolonged exposure to light. Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu LY75/DEC-205

Target: LY75/DEC-205 (LY75) (Lymphocyte Antigen 75 (LY75))

Andere Bezeichnung: CD205

Hintergrund: CD205, also known as DEC-205 and LY75, belongs to the macrophage mannose receptor (MMR) family of C-type lectins. Both human and mouse CD205 share multiple similar structures: an N-terminal cysteine-rich domain, a fibronectin type II domain, and a series of 10 tandemly repeated C-type like domains (CTLDs). CD205 is highly expressed on dendritic cells and thymic cortical epithelial cells in humans and mice. It also can be detected on T and B cells, monocytes, neutrophils, and epithelial cells. CD205 is a novel endocytic receptor used by dendritic cells and thymic epithelial cells to direct captured antigens from the extracellular space to specialized antigen processing areas. It mediates antigen uptake and presentation and cross-presentation to T cells. It has been reported that CD205 acts as a recognition receptor for dying cells, which potentially provides an important pathway for the uptake of self-antigen in the intrathymic environment, and is involved in peripheral tolerance.