PROCR Antikörper (PE)

Produktnummer ABIN2662523

Produktdetails anti-PROCR Antikörper (PE)

Target: PROCR (Protein C Receptor, Endothelial (PROCR))

Reaktivität: Human

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser PROCR Antikörper ist konjugiert mit PE

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF)

Aufreinigung: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Klon: RCR-401

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from prolonged exposure to light. Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu PROCR

Target: PROCR (Protein C Receptor, Endothelial (PROCR))

Andere Bezeichnung: CD201 (PROCR Produkte)

Synonyme: PROCR antikoerper, CCCA antikoerper, CCD41 antikoerper, EPCR antikoerper, AI325044 antikoerper, Ccca antikoerper, Ccd41 antikoerper, Epcr antikoerper, protein C receptor antikoerper, protein C receptor, endothelial antikoerper, PROCR antikoerper, Procr antikoerper

Hintergrund: Endothelial protein C receptor (EPCR), also known as CD201, is a 46 kD N-glycosylated type I transmembrane protein primarily expressed on the endothelial cells of arteries and veins in heart and lung. It is also expressed at high levels on a subset of hematopoietic stem cells and a subset of dendritic cells. CD201 functions as a primary receptor for protein C activation, which results in inhibition of both intrinsic and extrinsic coagulation pathways. It also plays an important role in many pathophysiologic processes, such as inflammation responses to infection, trauma, hematopoiesis, and autoimmune response. Deletion of the CD201 gene in knock-out mice leads to embryonic lethality before embryonic day 10, indicating that CD201 expression is critical for embryo development. In humans, mutations of CD201 have been associated with venous thromboembolism and myocardial infarction as well as with late fetal loss during pregnancy.