The L363 antibody reacts with α-GalCer:mouse CD1d complex. Glycolipid α-galactosylceramide (α-GalCer) is a potent activator of human and murine iNKT cells and is widely used as a model antigen for the studies of i NKT-mediated immunity. The glycolipid binds to CD1d and forms a complex which is subsequently recognized by i NKT cells, a subset of T cells expressing invariant TCR α chain Vα14, analogous to the peptide-MHC complex recognition by TCR α/ß T cells.
Aufreinigung
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Klon
L363
Isotyp
IgG2a kappa
Applikationshinweise
Optimal working dilution should be determined by the investigator.