IKZF2 Antikörper (Pacific Blue)

Produktnummer ABIN2662339

Der Armenischer Hamster Monoklonal anti-IKZF2 Antikörper wird verwendet zum Nachweis von IKZF2 in Proben von Human und Maus. Er wurde validiert für FACS.

Kurzübersicht für IKZF2 Antikörper (Pacific Blue) (ABIN2662339)

Target: IKZF2 (IKAROS Family Zinc Finger 2 (IKZF2))

Reaktivität: Human, Maus

Wirt: Armenischer Hamster

Klonalität: Monoklonal

Konjugat: Dieser IKZF2 Antikörper ist konjugiert mit Pacific Blue

Applikation: Flow Cytometry (FACS)

Klon: 22F6

Produktdetails anti-IKZF2 Antikörper (Pacific Blue)

Aufreinigung: The antibody was purified by affinity chromatography, and conjugated with Pacific Blue™ under optimal conditions. The solution is free of unconjugated Pacific Blue™.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from prolonged exposure to light. Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu IKZF2

Target: IKZF2 (IKAROS Family Zinc Finger 2 (IKZF2))

Andere Bezeichnung: Helios

Hintergrund: Helios is a member of the Ikaros family of zinc finger transcription factors. It contains a C-terminal region composed of 2 zinc-finger domains that mediate dimerization between the family members. Helios was originally cloned from a mouse thymoma line. It is mainly expressed in peripheral T cells and thymocytes. It is found at high levels in a subpopulation of regulatory T cells. Helios plays an important role in T cell development and homeostasis. Overexpression of Helios profoundly alters αβ T cell differentiation and activation. It has been determined that silencing of Helios in B cells is critical for maintaining normal B cell function. Helios is also involved in tumor immunity.