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TRA-1-60(R) Antikörper (Biotin)

Dieses Anti--Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von in FACS, WB, IP, ICC und IF. Geeignet für Human.
Produktnummer ABIN2661341

Kurzübersicht für TRA-1-60(R) Antikörper (Biotin) (ABIN2661341)

Target

TRA-1-60(R)

Reaktivität

Human

Wirt

  • 5
Maus

Klonalität

  • 5
Monoklonal

Konjugat

  • 2
  • 1
  • 1
  • 1
Biotin

Applikation

Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF)

Klon

TRA-1-60-R
  • Aufreinigung

    The solution is free of unconjugated biotin.

    Isotyp

    IgM kappa
  • Applikationshinweise

    Optimal working dilution should be determined by the investigator.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    0.5 mg/mL

    Buffer

    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Do not freeze.

    Lagerung

    4 °C

    Informationen zur Lagerung

    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Target

    TRA-1-60(R)

    Andere Bezeichnung

    TRA-1-60-R

    Hintergrund

    TRA-1-60-R antibody recognizes the neuraminidase resistant form of TRA-1-60. TRA-1-60 is a 200-240 kD cell surface antigen expressed by human embryonic stem cells (ESC), embryonic germ cells (EG), and embryonal carcinoma cells. The expression of TRA-1-60 on human ESC is downregulated upon differentiation. The soluble form of TRA-1-60 has been found in the serum of patients with embryonic cancers. Historically, TRA-1-60 is a neuroaminidase-sensitive (TRA-1-60-S) carbohydrate epitope expressed on podocalyxin, a member of the mucin-like glycoprotein CD34 family. Podocalyxin is a type I transmembrane sialoprotein with anti-adhesion properties. Further studies have shown that some of TRA-1-60 is neuraminidase resistant (TRA-1-60-R). The two forms of TRA-1-60 are essentially indistinguishable in terms of their cellular reactivity except for the difference in neuraminidase sensitivity. Both of TRA-1-60-S and TRA-1-60-R appear to be the same molecular weight glycoproteins detected by Western blot.
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