IL-33 Antikörper (AA 112-270) (Biotin)

Produktnummer ABIN2661328

Der Ziege Polyklonal anti-IL-33 Antikörper wird verwendet zum Nachweis von IL-33 in Proben von Human. Er wurde validiert für FACS.

Kurzübersicht für IL-33 Antikörper (AA 112-270) (Biotin) (ABIN2661328)

Target: IL-33 (IL33) (Interleukin 33 (IL33))

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser IL-33 Antikörper ist konjugiert mit Biotin

Applikation: Flow Cytometry (FACS)

Klon: Poly5163

Produktdetails anti-IL-33 Antikörper (Biotin)

Bindungsspezifität: AA 112-270

Kreuzreaktivität (Details): In sandwich ELISA, no cross-reactivity with mouse or rat IL-33.

Aufreinigung: The antibody was purified by antigen affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.

Immunogen: AA 112-270 (Accession# NM_033439) was expressed in E. coli.

Isotyp: Ig Fraction, IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 1 % BSA and 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu IL-33

Target: IL-33 (IL33) (Interleukin 33 (IL33))

Andere Bezeichnung: IL-33

Hintergrund: IL-33, also known as NFHEV and DVS 27, is a 30 kD proinflammatory protein that belongs to IL-1 superfamily. IL-33 is constitutively expressed in smooth muscle and airway epithelia. It is upregulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1α or IL-1β stimulation. IL-33 interacts with IL1RL1/ST2 receptor and IL-1 receptor accessory protein (IL1RAP) in order to activate intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. Recombinant IL-33 has been shown to enhance Th2-associated immune responses and potently increase mast cell proliferation and cytokine production.

Pathways: Production of Molecular Mediator of Immune Response