Integrin beta 7 Antikörper (Biotin)

Produktnummer ABIN2661247

Der Biotin-konjugierte Ratte Monoklonal anti-Integrin beta 7 Antikörper (Klon FIB504) (ABIN2661247) detektiert spezifisch Integrin beta 7 in FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für Integrin beta 7 Antikörper (Biotin) (ABIN2661247)

Target: Integrin beta 7 (ITGB7)

Reaktivität: Human, Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser Integrin beta 7 Antikörper ist konjugiert mit Biotin

Applikation: Flow Cytometry (FACS)

Klon: FIB504

Produktdetails anti-Integrin beta 7 Antikörper (Biotin)

Kreuzreaktivität: Schimpanse, Pavian, Cynomolgus, Rhesusaffen

Aufreinigung: The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu Integrin beta 7

Target: Integrin beta 7 (ITGB7)

Andere Bezeichnung: Integrin Beta7

Hintergrund: Integrin β7 is a 130 kD glycoprotein also known as integin βp. It is a member of the Ig superfamily. In association with integrin α4 or αE chain, β7 forms α4/β7 or αE/β7 heterodimer. α4/β7 (CD49d/β7, LPAM-1) is expressed on the majority of peripheral lymphocytes, on small subsets of thymocytes, and bone marrow progenitors. LPAM-1 binds to several ligands, VCAM-1, MAdCAM-1 and fibronectin, and is involved in lymphocyte adhesion and some hematopoietic progenitor cells migration. αE/β7 (CD103/β7,αIEL/β7) is expressed on intestinal intraepithelial lymphocytes (IEL), dendritic epidermal T cells, T regulatory cells, a subset of CD8+ T cells in lymph nodes and lamina propria. CD103/β7 complex is thought to play a role in lymphocyte retention via interaction with its ligand E-Cadherin.

Pathways: Integrin Complex