IL17F Antikörper (Biotin)

Produktnummer ABIN2661211

Der Maus Monoklonal anti-IL17F Antikörper wird verwendet zum Nachweis von IL17F in Proben von Maus. Er wurde validiert für IHC, FACS, IF und CyTOF.

Kurzübersicht für IL17F Antikörper (Biotin) (ABIN2661211)

Target: IL17F (Interleukin 17F (IL17F))

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL17F Antikörper ist konjugiert mit Biotin

Applikation: Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF), Cytometry by Time of Flight (CyTOF)

Klon: 8F5-1A9

Produktdetails anti-IL17F Antikörper (Biotin)

Aufreinigung: The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu IL17F

Target: IL17F (Interleukin 17F (IL17F))

Andere Bezeichnung: IL-17F

Hintergrund: Interleukin 17F (IL-17F) is a 37 kD IL-17 family member. The IL-17 family consists of six members including IL-17 (also called IL-17A), IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F. IL-17F shares the strongest similarity to IL-17A and forms a homodimer or heterodimer with IL-17A. It is produced by Th17 cells, mast cells, basophils, and epithelial cells. IL-17F is an important regulator of inflammatory responses. It is involved in host defense against mucoepithelial infection by Staphylococcus aureus and Citrobacter rodentium. Overexpression of the IL-17F gene in the airways of mice is associated with airway neutrophilia, the induction of many cytokines, an increase in airway hyperreactivity, and mucus hypersecretion. IL-17F is also involved in cancer immunity and autoimmune responses. IL-17F, like IL-17A, depends on IL-17R for its signaling in vitro and in vivo. P38 MAPK, ERK1/2, Act1 (NF-kB activator protein 1), and TRAF6 are involved in IL-17F signaling.

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity