CD45RB Antikörper (APC-Cy7)

Produktnummer ABIN2660703

Dieses Ratte Monoklonal-Antikörper erkennt spezifisch CD45RB in IHC, IP, ICC, CyTOF und ELISA (Capture). Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für CD45RB Antikörper (APC-Cy7) (ABIN2660703)

Target: CD45RB

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CD45RB Antikörper ist konjugiert mit APC-Cy7

Applikation: Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC), Cytometry by Time of Flight (CyTOF), ELISA (Capture)

Klon: C363-16A

Produktdetails anti-CD45RB Antikörper (APC-Cy7)

Aufreinigung: The antibody was purified by affinity chromatography, and conjugated with APC/Cy7 under optimal conditions. The solution is free of unconjugated APC/Cy7 and unconjugated antibody.

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from prolonged exposure to light. Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu CD45RB

Target: CD45RB

Andere Bezeichnung: CD45RB

Hintergrund: CD45RB is an isoform of CD45 with exon 5 splicing (encodes B determinant). It is a 220 kD glycoprotein expressed on peripheral B cells, naive T cells, thymocytes, weakly on macrophages, and dendritic cells. It plays a critical role in TCR and BCR signaling. As T cells become activated and progress from naive to memory cells, CD45RB expression is downregulated. Additionally, functionally distinct CD4+ T cell subsets, which secrete differing cytokine profiles, can be separated by CD45RB intensity. The primary ligands for CD45 are galectin-1, CD2, CD3, CD4 and Thy-1.