CD93 Antikörper (APC)

Produktnummer ABIN2658294

Dieses Ratte Monoklonal-Antikörper erkennt spezifisch CD93 in IF. Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für CD93 Antikörper (APC) (ABIN2658294)

Target: CD93

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CD93 Antikörper ist konjugiert mit APC

Applikation: Immunofluorescence (IF)

Klon: AA4-1

Produktdetails anti-CD93 Antikörper (APC)

Aufreinigung: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from prolonged exposure to light. Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu CD93

Target: CD93

Andere Bezeichnung: CD93

Substanzklasse: Chemical

Hintergrund: CD93 is a 130-140 kD C-type lectin-like type I transmembrane protein, also known as complement component 1, q subcomponent (C1qR1), C1qRp collectin receptor (C1qRp), or AA4 antigen. It is a receptor expressed on immature B lymphocytes, hematopoietic progenitors and stem cells in adult bone marrow, fetal liver, and the embryonic yolk sac. CD93 expression levels on splenic immature/transitional B cells is much lower than in bone marrow. It is reinduced during plasma cell differentiation and plays an important role in maintaining plasma cells in bone marrow niches. Immature dendritic cells express CD93 and down-regulate this molecule upon maturation, suggesting they play a role in uptake of particles. CD93 is also expressed on monocytes, macrophages, and endothelial cells. Macrophages from CD93 (-/-) mice had a significant phagocytic defect in the clearance of apoptotic cells in vivo, indicating CD93 may contribute to the in vivo clearance of dying cells. The idea that CD93 binds to C1q remains controversial.