CCR7 Antikörper (Alexa Fluor 488)

Produktnummer ABIN2657353

Der Maus Monoklonal Anti-CCR7-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, CCR7 in Proben von Human zu detektieren.

Kurzübersicht für CCR7 Antikörper (Alexa Fluor 488) (ABIN2657353)

Target: CCR7 (Chemokine (C-C Motif) Receptor 7 (CCR7))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CCR7 Antikörper ist konjugiert mit Alexa Fluor 488

Applikation: Western Blotting (WB), ELISA

Klon: G043H7

Produktdetails anti-CCR7 Antikörper (Alexa Fluor 488)

Kreuzreaktivität: Cynomolgus, Rhesusaffen, Pavian

Aufreinigung: The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 488 under optimal conditions.

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from prolonged exposure to light. Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C

Details zu CCR7

Target: CCR7 (Chemokine (C-C Motif) Receptor 7 (CCR7))

Andere Bezeichnung: CD197

Hintergrund: CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Naive T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells, this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis.

Pathways: Regulation of Actin Filament Polymerization, Positive Regulation of Immune Effector Process