Cutaneous Lymphocyte Antigen Antikörper (Alexa Fluor 647)

Produktnummer ABIN2657191

Der Ratte Monoklonal anti-Cutaneous Lymphocyte Antigen Antikörper wird verwendet zum Nachweis von Cutaneous Lymphocyte Antigen in Proben von Human und Maus. Er wurde validiert für FACS.

Kurzübersicht für Cutaneous Lymphocyte Antigen Antikörper (Alexa Fluor 647) (ABIN2657191)

Target: Cutaneous Lymphocyte Antigen

Reaktivität: Human, Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Alexa Fluor 647

Applikation: Flow Cytometry (FACS)

Klon: HECA-452

Produktdetails

Aufreinigung: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.

Isotyp: IgM kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from prolonged exposure to light. Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C

Antigendetails

Target: Cutaneous Lymphocyte Antigen

Hintergrund: Cutaneous lymphocyte antigen (CLA) is a 140 kD homodimer protein recognized by a unique mAb, HECA-452. It is expressed on T cells in skin, subsets of peripheral blood memory T cells, NK cells, memory B cells and dendritic cells as well as on monocytes, granulocytes, and activated endothelial cells. CLA is a carbohydrate epitope of sialic acid and fucose-modified P-selectin glycoprotein ligand-1 (PSGL-1), a surface glycoprotein expressed on the majority of peripheral blood leukocytes. CLA is a ligand for E-selectin, P-selectin, and L-selectin. It plays a role in memory lymphocyte homing, tethering, and rolling.