HDAC9 Antikörper

Produktnummer ABIN265461

Produktdetails anti-HDAC9 Antikörper

Target: HDAC9 (Histone Deacetylase 9 (HDAC9))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HDAC9 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of HDAC9 protein. (region surrounding Pro1047)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Reinheit: > 95 % pure by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200. IF: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: DO NOT FREEZE!

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu HDAC9

Target: HDAC9 (Histone Deacetylase 9 (HDAC9))

Andere Bezeichnung: HDAC9 (HDAC9 Produkte)

Synonyme: HD7 antikoerper, HD7b antikoerper, HD9 antikoerper, HDAC antikoerper, HDAC7 antikoerper, HDAC7B antikoerper, HDAC9B antikoerper, HDAC9FL antikoerper, HDRP antikoerper, MITR antikoerper, AV022454 antikoerper, D030072B18Rik antikoerper, HD7B antikoerper, Hdac7b antikoerper, Mitr antikoerper, mKIAA0744 antikoerper, hdac9 antikoerper, zgc:73392 antikoerper, TWIST antikoerper, HDAC9 antikoerper, DKFZp459E171 antikoerper, HDA09 antikoerper, HISTONE DEACETYLASE antikoerper, histone deacetylase 9 antikoerper, RGD1310748 antikoerper, RGD1563092 antikoerper, hdac9-A antikoerper, histone deacetylase 9 antikoerper, histone deacetylase 9b antikoerper, histone deacetylase 9 S homeolog antikoerper, HDAC9 antikoerper, Hdac9 antikoerper, hdac9b antikoerper, HDA9 antikoerper, hdac9.S antikoerper

Hintergrund: The remodeling of chromatin is a critical component of ranscriptional regulation and the acetylation of nucleosomal histones is a major source of this remodeling. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Several mammalian proteins function as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Conversely, the deacetylation of histones is associated with transcriptional silencing. The histone deacetylases (HDAC) include HDAC1-9. HDAC9 and HDAC9a are two alternatively spliced isoforms of HDAC9. HDAC9a is 132 amino acids shorter than HDAC9, but both isoforms contain the HDAC catalytic domain, remain capable of deacetylase activity and repress myoctye enhancer-binding factor 2-mediated transcription.Synonyms: HD7B, HD9, HDAC7B, HDRP, Histone deacetylase 9, Histone deacetylase-related protein, KIAA0744, MEF2-interacting transcription repressor MITR, MITR

Molekulargewicht: approx. 111, 160 kDa

Gen-ID: 9734

NCBI Accession: NP_001191073

UniProt: Q9UKV0

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development